Unit I Drugs - Simplified Flashcards Preview

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Flashcards in Unit I Drugs - Simplified Deck (45):
1

Furosemide Target

Thick ascending limb

2

Furosemide MOA

Inhibits NaCL cotransporter (inhibiting NKCC2, the luminal Na-K-2Cl symporter)

3

Furosemide Role in Tx of HF

decreases volume overload

4

Furosemide Adverse Effects

• Hypokalemic metabolic alkalosis
• Hyperuricemia

5

Furosemide Effects on K+

Decrease x2

6

Furosemide Notes

Efficacious

7

What kind of drug is Furosemide?

Loop Diuretics

8

What kind of drug is Hydrochlorothiazide?

Thiazide diuretic

9

Hydrochlorothiazide Target

Distal convoluted tube

10

Hydrochlorothiazide MOA

Inhibits NaCL cotransporter

11

Hydrochlorothiazide Role in Tx of HF

decreases volume overload

12

Hydrochlorothiazide Adverse Effects

Hypokalemia

13

Hydrochlorothiazide Effects on K+

Decreases

14

Hydrochlorothiazide notes

Supplements loop diuretic in HF

15

What kind of drug is Spironolactone/Eplerenone?

Potassium-sparing diuretic

16

Spironolactone/Eplerenone Target

Collecting tubule

17

Spironolactone/Eplerenone MOA

Aldosterone receptor antagonist

18

Spironolactone/Eplerenone role in Tx of HF

• anti-remodeling action (blocks aldosterone-mediated hypertrophy)
• RAAS antagonist

19

Spironolactone/Eplerenone Adverse effects

• Hyperkalemia
• Gynecomastia (Spiro)

20

Spironolactone/Eplerenone effects on K+

increases

21

Spironolactone/Eplerenone Notes

Aldosterone promotes Na+ retention

22

What kind of drug is Lisinopril?

RAAS Antagonist (Vasodilator) - ACEI

23

Lisinopril MOA

Inhibits conversion of AngI to AngII

24

Lisinopril role in Tx of HF

• inhibits AngII-induced vasoconstriction
• anti-remodeling action
• decreases bradykinin inactivation (increases vasodilation)

25

Lisinopril adverse effects

• Hyperkalemia
• Cough

26

Lisinopril effects on K+

Increases

27

What kind of drugs are Valsartan/Losartan?

RAAS Antagonists (vasodilator) - ARBs

28

Valsartan/Losartan MOA

AngII receptor (AT1) antagonist

29

Valsartan/Losartan role in Tx of HF

• anti-remodeling action
• inhibits AngII-induced vasocontriction

30

Valsartan/Losartan adverse effects

• Slow on/off rate due to long half-life
• Many DDIs

31

Valsartan/Losartan effects on K+

increases

32

Valsartan/Losartan notes

Used in pts intolerant to ACEIs

33

What kind of drug is Propranolol?

Beta blocker, not approved for use in HF

34

What kind of drug is Metoprolol?

Beta Blocker

35

Metoprolol Target

β2

36

Metoprolol MOA

β2 antagonist

37

Metoprolol Role in Tx of HF

• anti-remodeling action
• reduces HR to improve EF

38

What kind of drug is Carvedilol?

beta-blocker, gold standard

39

Carvedilol target

α1, β1, β2

40

Carvedilol MOA

α1, β1, β2 antagonist

41

Carvedilol role in Tx of HF

• anti-remodeling action
• reduces HR to improve EF

42

What kind of drugs is Digoxin?

Cardiac glycosides (positive inotrope)

43

Digoxin target

Na+/K+ ATPase

44

Digoxin MOA

• Na+/K+ ATPase antagonist
• increase in IC Na+ leads to increase in IC Ca2+

45

Digoxin role in Tx of HF

• improves CO, EF, and pump function