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HEMA II LEC > HEMA 2 LECTURE > Flashcards

HEMA 2 LECTURE Flashcards

(78 cards)

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1
Q

What quantitative WBC disorder is hairy cell
related to?

A

MONOCYTOPENIA

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2
Q

Aside from hairy cell, what viral disorder decreases monocytes?

A

Epstein-Barr virus

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3
Q

What if there will be obstruction in the lymphatic circulation, what WBC quantitative disorder is expected?

A

LYMPHOCYTOPENIA

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4
Q

Pertussis Infection

A

LYMPHOCYTOSIS

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5
Q

Protozoal Infection

A
  • MONOCYTOSIS
  • NEUTROPHILIA
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6
Q

After BM failure recovery

A

MONOCYTOSIS

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7
Q

Steroid therapy

A
  • NEUTROPHILIA
  • MONOCYTOPENIA
  • EOSINOPENIA
  • BASOPENIA
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8
Q

Physical Activity

A

NEUTROPHILIA

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9
Q

Overwhelming Infection

A

NEUTROPENIA

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10
Q

Hookworm infection

A

EOSINOPHILIA

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11
Q

Exposure to drug and allergens

A
  • BASOPHILIA
  • EOSINOPHILIA
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12
Q

LAP result in leukemoid reaction

A

INCREASED LAP

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13
Q

Decreased LAP score

A

CGL / CML

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14
Q

Leukoerythroblastic reaction can be present in what MPN?

A

Primary myelofibrosis

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15
Q

Disorder if there is absence of cell surface adhesion protein in WBC

A

LAD (Leukocyte Adhesion Deficiency)

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16
Q

Formation of large dark granules, associated with mucopolysaccharidosis

A

Alder-Reilly Anomaly

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17
Q

Giant granules of the cytoplasm of WBC

A

Chediak Higashi

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18
Q

Disorder representing bilobed neutrophil with dark staining nuclei

A
  • Pelger-Huet Anomaly
  • Other name: Neutrophil
  • Hyposegmentation
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19
Q

Enzyme released by eosinophil to form charcot-leyden crystals

A

LYSOPHOSPHOLIPASE

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20
Q

Term wherein WBC release content of granules

A

DEGRANULATION

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21
Q

Type of neutrophilia with redistribution of marginated granulocyte pool to circulating granulocyte pool; occurs 20-30 minutes

A

IMMEDIATE NEUTROPHILIA

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22
Q

Type of cells expected to see with “shift to the left”

A
  • BLASTS / BANDS
  • IMMATURE CELLS
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23
Q

Expected description of BM with high M:E Ratio

A
  • HYPERPLASIA
  • HYPERCELLULAR
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24
Q

Condition in which granulocytes cannot be released front the bone marrow

A

MYELOKATHEXIS

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25
Neutrophil precursors undergoing selective apoptotic death in newborns
KOSTMANN’S SYNDROME
26
Other term for Kostmann’s Syndrome
- INFANTILE GENETIC AGRANULOCYTOSIS
27
WBC to increase in agranulocytosis
Agranulocytes : mono and lympho
28
Between Job’s and Lazy Syndrome. Both random and directional motility impaired
Lazy Syndrome
29
Job’s Syndrome, what is impaired
Directional motility
30
Condition with strong oxidant deficiency
Myeloperoxidase deficiency
31
Replacement of BM cells by malignant cells
- Primary myelofibrosis - MMM
32
WBC with Dohle inclusion in cytoplasm and presence of giant platelets
May Hegglin Anomaly
33
No dohle inclusion body with presence of giant platelets
Bernard Soulier disease
34
Deficient in enzyme glucocerebrosidase
GAUCHER DISEASE
35
Enzyme deficient in Niemann Pick disease
Sphingomyelinase
36
Specific WBC that serves as hallmark of megaloblastic anemia
- Hypersegmented neutrophil - Neutrophil Hypersegmentation
37
Giant brown granules resulting to impaired bactericidal activity
Chediak Higashi
38
Cells / lineage involved with primary myelofibrosis. (increase)
Granulocytes and megakaryocytes
39
Primary myelofibrosis. Expected mutated gene
JAK2, MPL, CLA-R
40
Aside from myelofibrosis, what MPN also has 3 mutation
Essential thrombocytopenia
41
Predominant cell increased in polycythemia vera
Erythrocytes
42
In PCV, 90-95 % patients will have this mutation
JAK2V617F
43
Acute lymphobasltic leukemia, L1
Small homogenous lymphoblast
44
Is your L3 the same with Burkitt’s Lymphoma?
- NAUR! - Burkitt’s Lymphoma: mature cells - L3: “burkitt type” only, lymphoblasts
45
Where does Burkitt’s Lymphoma belong, Hodgkin or Non-Hodgkin?
Non-Hodgkin’s Lymphoma
46
L3. expected appearance of cells
Both nucleus and cytoplasm have VACUOLES
47
Multiple myeloma
Plasma cells
48
Non-hodkin’s lymphoma. What type of cells can be seen?
- B-lymphocytes with normal morphology - Neoplasmic cell
49
M7
Megakaryoblast
50
M5a
- “Schilling’s Leukemia” - Monoblast, immature cells
51
M2
Myeloblast with granulocytes
52
Start appearance of auer rods
M1
53
M4Eo
Myelomonocytes and Eosinophils
54
DIC
M3 (Hypergranular)
55
Type of leukemia with myelocyte cells usually mature stages
Chronic
56
Condition with predominantly mature cells involved
- MPN (MYELOPROLIFERATIVE NEOPLASM)
57
Cytopenia, ineffective hematopoeisis, increased apoptosis
- Dysplasia - MDS
58
Type of mutation occurring in chromosomes
Somatic mutation
59
Diagnosis for AML. what is the basis of WHO?
- >20% blasts - FAD: >30%
60
Malignancy with fusion of BCR-ABL region of chromosome
CML / CGL
61
BCR-ABL is what type of chromosome?
- Philadelphia chromosome - Translocation between the long arms of chromosome 9 and 22
62
Chronic / Acute. Both blast and mature cells involved
Acute
63
Myeloproliferative disorder with increased granulocytes (neu, baso, eo)
CGL / CML
64
Expected EPO level with primary polycthemia
- Decreased or normal - Other name: Osler’s or polycythemia rubra vera - Malignant - does not respond to level of EPO - If secondary - increased
65
Two inclusion in cells involved in AML
- Auer rods - Phi bodies
66
AMLs with presence of Auer rods
M1, M2, M3m/v, M6
67
Other term for acute erythroleukemia
- Di guglielmo leukemia - M6
68
Type of AML with high platelet
M7
69
L1, L2, L3 increase with
- Age and severity - Homogenous / heterogenous: morphology
70
Lymphocytosis with smudge cells
CLL
71
Predominant chromatin pattern of smudge cell
Soccer ball ; cobblestone appearance
72
How can we stain hairy cells
TRAP
73
Morphology of BM with many hairy cells
Fried egg appearance
74
BM sample collection (hairy cells)
Dry tap
75
Between AML and ALL. which is more common in children
ALL
76
Lymphocytes with folded/ cerebriform nucleus
- Mycosis Fungoides / Sezary Syndrome - Mycosis fungoides: benign, cutaneous - Sezary Syndrome: malignant, systemic
77
Neoplastic cell involved in Hodgkin’s lymphoma
Reed sternberg cell
78
Correlation between increased ESR in multiple myeloma
Ig in plasma cell → ↓ zeta potential (less - charge) → rouleaux formation → ↑ ESR

HEMA II LEC (6 decks)

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