MODULE 3

Question 1

Platelets arises from a unique cell of the bone marrow known as?

Answer 1

Megarkaryocyte

Question 2

How many megakaryocytes are seen in 10x low power field?

Answer 2

2-4 megakaryocytes

Question 3

What progenitor cell that will differentiate eventually into the formation of megakaryocytes and platelets?

Answer 3

CFU-GEMM

Question 4

Megakaryocyte differentiation can also be suppressed by another transcription gene

Answer 4

MYB

Question 5

Megakaryocyte are under what lineage?

Answer 5

Common myeloid progenitor cell

Question 6

This is a counterpart of megakaryocyte lineage from erythrocyte lineage?

Answer 6

BFU-Meg/Burst Forming Unit-Megakaryocyte

Question 7

Formation of hundreds colonies

Answer 7

BFU-Meg/ Burst Forming Unit-Megakaryocyte

Question 8

Only produce dozens of the colonies

Answer 8

CFU/Colony Forming Unit-Megakaryocyte

Question 9

Undergoes unique type of mitosis which is endoreduplication/endomitosis

Answer 9

LD-CFU-Meg/ Light Density - Colony Forming Unit- Megakaryocyte

Question 10

Mitosis happens within the nucleus but there is no cytoplasmic dividion

Answer 10

Endomitosis

Question 11

Friend of GATA1, a transcription factor or gene which facilitates and help for the function of GATA1

Answer 11

FOG1

Question 12

Mediates the switch from mitosis to endomitosis

Answer 12

RUNX1

Question 13

This pathway is needed for cytokinesis to take place

Answer 13

Rho/ROCK Pathway

Question 14

Responsible for polyploidization

Answer 14

NF-E2

Question 15

Earliest pre-cursor and the most immature recognizable cell in the lineage

Answer 15

Blast cell

Question 16

There is a plasma membrane blebs or blunt projections

Answer 16

Megakaryoblast (MK-I)

Question 17

This stage is the end of endomitosis

Answer 17

Promegarkaryocyte (MK-II)

Question 18

The cytoplasm is azurophilic or lavender and granular and the endomitosis is absent

Answer 18

Megakaryocyte (MK-III)

Question 19

Stain used to recognize the formation of lobules in megakaryocyte

Answer 19

Propidium Iodide

Question 20

If it is still attached from the membrane

Answer 20

Proplatelets

Question 21

Unique structure of megakaryocyte

Answer 21

Demarcation Membrane

Question 22

Formation of bleb and pseudopodia is due to

Answer 22

Disarrangement or deformation of microtubules

Question 23

TPO receptor site present at all maturation stages

Answer 23

MPL/Myeloproliferative Leukemia

Question 24

Stem cell and common myeloid progenitor marker, disappears as differentiation proceeds

Answer 24

CD34

Question 25

Main hormone or growth factor which needed for the maturation of the platelet

Answer 25

Thrombopoietin

Question 26

Only present until the LD-CFU-Meg

Answer 26

CD34

Question 27

Can only be detected in MK-III and platelet

Answer 27

Cytoplasmic Coagulation

Question 28

Circulates as a hormone in plasma and is the ligand that binds the megakaryocyte in and MPL

Answer 28

Thrombopoietin

Question 29

Act in synergy with TPO to induce the early differentiation of stem cells

Answer 29

IL-3

Question 30

Act in the presence of TPO to enhance endomitosis megakaryocyte maturation and thrombocytopoeisis

Answer 30

IL-5 AND IL-77

Question 31

Also known as kit ligand or mast cell growth factor

Answer 31

Stem Cell Factor

Question 32

Lifespan of platelets

Answer 32

7-10 days

Question 33

Other term for thrombocytopoeisis

Answer 33

Platelet shedding/budding, thrombopoeisis

Question 34

Shape of platelets in EDTA

Answer 34

Round up

Question 35

Counter part of Mean Corpuscular Volume that measures the volume of the RBC

Answer 35

Mean Platelet Volume

Question 36

Pieces of megakaryocyte cytoplasm which is formed because of platelet shedding

Answer 36

Platelets

Question 37

Once platelet is activated, there is a formation of what

Answer 37

Pseudopods/Filopodia

Question 38

Same size with RBC, premature release and increased demand

Answer 38

Giant Platelet

Question 39

If there would be an increased presence of giant platelets, it would result to

Answer 39

Falsely elevated RBC count

Question 40

Immature platelets can be seen in

Answer 40

Acute Megakaryocytic Leukemia

Question 41

Appear in compensation for thrombocytopenia

Answer 41

Stress Platelets

Question 42

If there is a decreased platelets in the circulation, the bone marrow will

Answer 42

Increase the production of megakaryocytes

Question 43

Located centrally and is granular

Answer 43

Chromomere/Granulomere

Question 44

Surrounds the chromomere/platelets and is nongranular or clear to light blue

Answer 44

Hyalomere

Question 45

Chromomere/Granulomere contains

Answer 45

Alpha granules and glycogen granules

Question 46

Carry the receptors for important function of the platelets

Answer 46

Glycoprotein structure

Question 47

Serves as site of arachidonic acid synthesis or pathway

Answer 47

Phosphatidylinositol

Question 48

Responsible for the formation of prostaglandin and thromboxane

Answer 48

Arachidonic acid

Question 49

Receptors that responds to cellular and humoral stimuli

Answer 49

Ligadns/Agonist

Question 50

Exterior coat with glycoprotein receptor sites

Answer 50

Glycocalyx

Question 51

An integrin that binds the subendothelial collagen promoting adhesion of the platelets

Answer 51

Gp Ia/IIa

Question 52

Collagen binder receptor and member of the immunoglobin gene family

Answer 52

Gp VI

Question 53

Receptor that also binds the adhesive protein thrombospondin

Answer 53

Gp IV

Question 54

Can cross the platelet membrane and interact with acting-binding protein

Answer 54

Gp IbB

Question 55

Binds fibrinogen

Answer 55

Gp IIb/IIa

Question 56

Generating interplatelet cohesion

Answer 56

Gp IIb/IIIIIa

Question 57

Anchors plasma membrane Gp and proteoglycans

Answer 57

Microfilaments