MODULE 1

Question 1

Pale blue oval remnants if free ribosomes or RER

Answer 1

Dohle Bodies

Question 2

Large blue-black azurophilic cytoplasmic granules; less peroxidase

Answer 2

Toxic Granulation

Question 3

Nucleus does not segment beyond the two-lobed stage; bilobed/rounded with pince-nez/ dumbbell peanut shape

Answer 3

Pelger-huet Anomaly

Question 4

Larger than normal neutrophils with six or more nuclear segments

Answer 4

Neutrophil Hypersegmentation

Question 5

Larger dark cytoplasmic granules in leukocytes; cells function normally

Answer 5

Alder-Reilly Anomaly

Question 6

Giant fused granules in the neutrophils, monocytes and lymphocytes; engulf but do not kill microorganism

Answer 6

Chediak-Higashi Syndrome

Question 7

Blue, dohle like cytoplasmic inclusions in ALL; giant platelets are present

Answer 7

May-Hegglin Anomaly

Question 8

Lack of b-glucosidase resulting to accumulation of glucocerobroside

Answer 8

Gaucher Disease

Question 9

Deficiency in sphingomyelinase

Answer 9

Niemann-pick disease

Question 10

In toxic granulation, what granules predominate?

Answer 10

Primary/Azurophilic/Non-specific granules

Question 11

Directional motility of phagocytes is impaired

Answer 11

Job’s Syndrome

Question 12

Both random and direct movement of the cells are defective

Answer 12

Lazy Leukocyte Syndrome

Question 13

There is a chronic infection and formation of granuloma

Answer 13

Chronic granulomatous disease

Question 14

Low or absent myeloperoxidase enzyme; strong oxidants

Answer 14

Myeloperoxidase Deficiency

Question 15

Defective leukocyte adhesion

Answer 15

Leukocyte Adhesion Deficiency

Question 16

Lack of secondary/specific cytoplasmic granules

Answer 16

Specific Granule Deficiency

Question 17

Increased in WBC count and mimics the blood picture of CML

Answer 17

Neutrophilic Leukemoid Reaction

Question 18

Presence of immature leukocytes and immature erythrocytes; space occupying lesion in the bone marrow

Answer 18

Leukoerythroblastic Reaction

Question 19

Result from an unchecked, autonomous clonal proliferation

Answer 19

Myeloproliferative Neoplasm

Question 20

Characterized by leukocytosis with an increase immature and immature cells of the granulocytic series

Answer 20

Chronic Myelogenous Leukemia

Question 21

Affecting primarily the erythroid series associated with normal/decreased EPO levels

Answer 21

Polycythemia Vera

Question 22

Affecting the megakaryocytic lineage with manifestation of thrombocytosis

Answer 22

Essential Thrombocytopenia

Question 23

Caused by mutations in 60% JAK2, 30% CALR, 5% MPL mutations

Answer 23

Primary Myelofibrosis

Question 24

Ineffective hematopoiesis and increased apoptosis

Answer 24

Myelodysplastic Syndrome

Question 25

Dry tap, fried egg bone marrow

Answer 25

Hairy Cell Leukemia