HEMAQE

Question 1

Which of the following reagents used for
Cyanmethemoglobin method has the
purpose of reducing the incubation time of
solution

Answer 1

Sodium bicarbonate

Question 2

What is the expected end-point result of
performing Protamine Sulfate Dilution in
samples with abnormal specimens?

Answer 2

Paracoagulation

Question 3

In performing plasminogen assay, which of
the following converts plasminogen to
plasma?

Answer 3

Streptokinase

Question 4

A 10-year-old female child has developed
microangiopathic hemolytic anemia
secondary to kidney acute renal failure
after infection with E. coli 0157:H7. Other
significant laboratory results were
decreased platelet count and the presence
of casts and protein in the urine. What is
most likely the cause of the diagnosis for
the patient?

Answer 4

Hemolytic uremic syndrome

Question 5

Which of the following RBC inclusions can
possibly be seen with Megaloblastic
anemia?

Answer 5

Cabot ring

Question 6

Which RBC indices are used as parameters
in classifying anemias based on
morphology?

Answer 6

MCV and MCHC

Question 7

What causes prolongation in Stypven time?

Answer 7

There is a presence of lupus anticoagulant

Question 8

In the direct method for platelet count, what is the total magnification used when
examining the platelets?

Answer 8

100x

Question 9

What red blood cell index reflects the red
blood size?

Answer 9

Mean corpuscular volume

Question 10

How much hemoglobin is equivalent to
1mm reading of hematocrit?

Answer 10

0.34 grams of hemoglobin

Question 11

Which of the following pathways
generates 2,3-BPG and enhances oxygen
delivery to tissues?

Answer 11

Rapport-leubering Pathway

Question 12

What test aids in assessing the normal
function of the adrenal gland?

Answer 12

Eosinophil Depression Test

Question 13

Which condition involves oculataneous
albinism in children with Swiss cheese appearance of platelets?

Answer 13

Hermansky-Pudlak syndrome

Question 14

What is the objective lens used in counting
the red blood cells?

Answer 14

HPO

Question 15

Which RBC indices best reflect a normal
red blood cell?

Answer 15

MCV=93 fL; MCHC = 34 g/dL

Question 16

An 18-year-old female patient has been
prone to hemorrhage since she was a child.
Which substance is most likely to be
deficient?

Answer 16

Procoagulant substances

Question 17

What is the appearance of the resting and
circulating platelets?

Answer 17

Biconvex disc shaped

Question 18

You perform a whole blood
lumiaggregometry on a specimen from a
patient who complains to have excessive
beleeing from minor cuts. The following
clinical findings gives a normal aggregation
with ristocetin. What is the most likely
related disorder?

Answer 18

Glanzmann Thrombasthenia

Question 19

What is being quantified by the Nitroblue
Tetrazolium test?

Answer 19

Neutrophil

Question 20

Which lymphoid neoplasm is characterized
by peripheral blood lymphocytosis
composed of cells with cobblestone or
soccer ball chromatin pattern?

Answer 20

Chronic lymphocytic leukemia

Question 21

Which of the following best describes a
hyperchromic Red Blood Cells?

Answer 21

RBCs tent to lyse easily due to have an
increased hemoglobin concentration

Question 22

Which is the correct method that uses 40-
60 mmHg pressure to test for bleeding
time?

Answer 22

Ivy method

Question 23

What could be the possible factor
deficiency if the Prothrombin Time is
prolonged but all other test results are
normal?

Answer 23

Factor VII deficiency

Question 24

Which is not present in aged serum?

Answer 24

Factor V

Question 25

Using a Modified Fonio’s Method, Martin counted 35 platelets on 10 consecutive oil immersion fields, what is the total platelet count of the patient?

Answer 25

700,000 platelets/uL

Question 26

What is the length of time required to form a clot in vitro under standard conditions?

Answer 26

Clotting Time

Question 27

Which synthesizes the role of vWF and fibrinogen in primary hemostasis?

Answer 27

vWF participates in collagen binding while fibrinogen binds to adjacent platelets

Question 28

Which of these is the best site of choice for skin puncture in adults?

Answer 28

Palmar surface of the distal portion of the middle and ring finger on the non-dominant hand

Question 29

What is the immediate reaction of the hemostatic system upon injury?

Answer 29

Vasoconstriction

Question 30

Which is the last step in primary hemostasis?

Answer 30

Platelet adherence to one another

Question 31

A normal hemoglobin has iron in which of the following states?

Answer 31

Ferrous

Question 32

What is the standing time after the tubes for OFT have been gently shaken?

Answer 32

2 hours

Question 33

In a normally maturating blood cell, what should happen to the proportion of the cytoplasm to the nucleus?

Answer 33

Increasing

Question 34

Why is there a decreasing level of basophilia in the cytoplasm as the cell matures?

Answer 34

The decrease in RNA of the cell will cause a lesser affinity for a basic dye

Question 35

In Sahli-Adams method for hemoglobin determination, what is the reagent that we use to convert hemoglobin to hematin?

Answer 35

0.1 N hydrochloric acid

Question 36

How can you differentiate AML from ALL using the Sudan Black B stain?

Answer 36

AML is positive while ALL is negative for SBB

Question 37

What subtype of acute myelogenous leukemia is associated with high incidence of DIC?

Answer 37

Acute promyelocytic leukemia, hypergranular variant

Question 38

What are the reagents used in performing activated partial thromboplastin time?

Answer 38

Calcium, partial thromboplastin

Question 39

A 29-year-old woman with a history of a blood disorder presents to the clinic for follow-up after a hospitalization for a vasco-occlusive pain crisis complicated by influenza A. Her lab findings: hemoglobin electrophoresis: 92% Hb S, 6% Hb F, 2% Hb A2; PBS: anisopoikilocytosis and boatshaped erythrocytes. Which of the following RBC defect/s is/are involved in this patient?

Answer 39

Functional abnormality of hemoglobin and membrane damage

Question 40

Which of the following best describes where D-dimer is produced from?

Answer 40

Cross linked and stabilized fibrin clot

Question 41

A woman has developed a massive blood clot in her left leg resulting in occlusion of normal blood flow. What property of the vascular intima is most likely deficient or nearly absent in this clinical presentation?

Answer 41

Anticoagulant property

Question 42

On a well stained blood film, what is the color of cytoplasm of the monocytes?

Answer 42

Blue gray

Question 43

What protein neutralizes free plasmin?

Answer 43

Alpha-2 antiplasmin

Question 44

Which is due to abnormally increased platelet reactivity and increased sensitivity to platelet agonists?

Answer 44

Sticky platelet syndrome

Question 45

Which of the following granulocyte precursor cells has a round oval, quadrangular nucleus with fine-reddish purple chromatin and the cytoplasm generally lacks granules?

Answer 45

Myeloblast

Question 46

Which is the major site of T cell maturation and differentiation?

Answer 46

Thymus

Question 47

Which of the following is the main negative regulator of intestinal iron absorption?

Answer 47

Hepcidin

Question 48

Which coagulation factor is dependent on Vitamin K to produce a functional structure?

Answer 48

Factor X

Question 49

Which is an in-vitro phenomenon wherein thrombocytes surround neutrophils?

Answer 49

Platelet satellitosis

Question 50

During bone marrow recovery, why are monocytes predominantly see in the peripheral blood and not neutrophils?

Answer 50

Monocytes are immediately released upon maturation

Question 51

. Which can kill certain tumor cells, microbial agents and virus-infected cells without prior sensitization/exposure?

Answer 51

Natural killer cells

Question 52

What is the recommended plasma sample used for coagulation tests?

Answer 52

<10,000/uL PPP

Question 53

A shift to the left in the PBS means an increase in which type of cells?

Answer 53

Immature granulocytes

Question 54

Which structure in the vascular intima secretes the von Willebrand factor?

Answer 54

Endothelial cells

Question 55

The erythroid precursors in the bone marrow surround which of the following cells?

Answer 55

Macrophage

Question 56

How does the increased oxygen delivery to the kidneys affect the erythropoietic process?

Answer 56

Reduced stimulus for erythropoietin production

Question 57

What abnormal hemoglobin is formed when the iron is oxidized to its ferric state?

Answer 57

Methemoglobin

Question 58

Which scenario corresponds to the effect of fibrinolytic inhibitors?

Answer 58

Decreased fibrinolysis- leading to thrombosis

Question 59

Which of the following WBCs produce heparan sulfate, the body’s natural anticoagulant?

Answer 59

Basophils

Question 60

Which is the first progenitor cell that undergoes endomitosis in megakaryocytopoiesis?

Answer 60

LD-CFU-Meg

Question 61

This RBC inclusion describes as a ‘bar of gold’ is commonly observed in which condition?

Answer 61

Hb CC

Question 62

Which cytokine is involved in the differentiation and maturation of Basophil?

Answer 62

IL-3 and TSLP

Question 63

What is the objective lens used in WBC differential counting?

Answer 63

OIO

Question 64

Patients with leukemia who undergo chemotherapy treatments would usually have _____ levels of white blood cells and ____ levels of platelets in their laboratory results using hematology analyzers

Answer 64

Falsely decreased white blood cells; Falsely increased platelets

Question 65

The elevation of which of the following molecules cannot cause an increased ESR?

Answer 65

Albumin

Question 66

How many smaller squares are there in one large corner square?

Answer 66

16 smaller squares

Question 67

What is released by platelets and that is primarily responsible for clot retraction?

Answer 67

Thrombosthenin

Question 68

Which is the other name of reticulocyte?

Answer 68

Diffuse basophilic erythrocyte

Question 69

A medical technologist was having a hard time doing the white blood cell differential count on the blood smears since the red blood cells are too pale and the white blood cells are barely visible. How will he fix the problem with the blood smears?

Answer 69

The staining time should be prolonged

Question 70

What anticoagulant is present in blue band capillary tubes?

Answer 70

No anticoagulant

Question 71

What substance on the intact vascular endothelium acts as an eicosanoid platelet inhibitor?

Answer 71

Prostacylin

Question 72

. How many WBCs are counted for routine differential counting?

Answer 72

100

Question 73

Which best represents the mechanism involved in Glanzmann thrombasthenia?

Answer 73

Inability of fibrinogen to bind with platelets

Question 74

What is the best RBC diluting fluid?

Answer 74

Dacie’s fluid

Question 75

Which is the purpose of examining the bone marrow using a core cylinder?

Answer 75

Estimate bone marrow cellularity

Question 76

What is the dilution factor if the blood is aspirated up to 0.2 mark of the WBC Thoma pipette?

Answer 76

50

Question 77

Which procoagulant has the highest concentration in the plasma

Answer 77

Fibrinogen

Question 78

What is the relationship between the fibrinogen concentration in the plasma and the time it takes to form a clot?

Answer 78

Inversely proportional

Question 79

Which is a resident macrophage in the lymph nodes?

Answer 79

Dendritic cell

Question 80

What is the concentration of sodium citrate used in coagulation tests?

Answer 80

0.105-0.109 M

Question 81

A man in his late 50s presents signs and symptoms of myeloproliferative neoplasm. To clinically diagnose the patient, the hematologist-oncologist orders cytogenetic analysis. Upon testing, the patient’s results show a mutation in the Jak2 gene. What disorder will be ruled out by the clinician in diagnosing the patient?

Answer 81

Chronic myelogenous leukemia

Question 82

Which is true about the role of ZPI?

Answer 82

Inhibit Xa with the help from Protein Z

Question 83

Which hemolytic anemia involves globin abnormality?

Answer 83

Sickle cell anemia

Question 84

Which is associated with toxic granulations in neutrophils?

Answer 84

Bacterial Infections

Question 85

Which of the following cytokines, stimulates the granulocytic colonies and differentiation of progenitors towards neutrophil lineage?

Answer 85

G-CSF

Question 86

Which represents the actual reticulocyte count per liter of whole blood?

Answer 86

ARC

Question 87

Which myeloproliferative disorder is characterized by thrombocytosis, abnormal platelet functions and a mutation in jak 1 and Jak 2 gene?

Answer 87

Essential thrombocythemia

Question 88

. Which causes a falsely prolonged PT and PTT?

Answer 88

Short draw

Question 89

What is the average diameter of a thrombocyte?

Answer 89

2-4 um

Question 90

. What can be observed at the bottom layer of the blood sample after centrifugation of an anticoagulated blood?

Answer 90

Red cell layer

Question 91

What is the average diameter of a thrombocyte?

Answer 91

2-4 um

Question 91

. What can be observed at the bottom layer of the blood sample after centrifugation of an anticoagulated blood?

Answer 91

Red cell layer

Question 92

When platelets fail to cease the contents of their granules and tubular systems, which of the following will immediately be affected?

Answer 92

Platelet activation

Question 93

Which refers to the variation in cell shape?

Answer 93

Poikilocytosis