Flashcards in Hematology Deck (13):
Heme synthesis, porphyrias, and lead poisoning
Factor V Leiden
Production of mutant factor V that is resistant to degradation by activated protein C. most common cause of inherited hypercoagulability in whites.
Prothrombin gene mutation
Mutation in 3' untranslated region -> inc production of prothrombin -> inc plasma levels and venous clots
Inherited deficiency of antithrombin: has no direct effect on the PT, PTT, or thrombin time but diminishes the increase in PTT following heparin administration.
Can also be acquired: renal failure/nephrotic syndrome -> antithrombin -> inc plasma levels and venous clots
Protein C or S deficiency
dec ability to inactivate factors V and VIII. inc risk of thrombotic skin necrosis with hemorhage following administration of warfarin. Skin and subcutaneous tissue necrosis after warfarin administration -> think protein C deficiency
Hodgkin vs non-hodgkin lymphoma