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Flashcards in Hematology Deck (13):
1

Coagulation cascade

FA 377

2

Thrombogenesis

FA 379

3

Anemias

FA 382

4

Heme synthesis, porphyrias, and lead poisoning

FA 388

5

Coagulation disorders

FA 389

6

Factor V Leiden

Production of mutant factor V that is resistant to degradation by activated protein C. most common cause of inherited hypercoagulability in whites.

7

Prothrombin gene mutation

Mutation in 3' untranslated region -> inc production of prothrombin -> inc plasma levels and venous clots

8

Antithrombin deficiency

Inherited deficiency of antithrombin: has no direct effect on the PT, PTT, or thrombin time but diminishes the increase in PTT following heparin administration.
Can also be acquired: renal failure/nephrotic syndrome -> antithrombin -> inc plasma levels and venous clots

9

Protein C or S deficiency

dec ability to inactivate factors V and VIII. inc risk of thrombotic skin necrosis with hemorhage following administration of warfarin. Skin and subcutaneous tissue necrosis after warfarin administration -> think protein C deficiency

10

Hodgkin vs non-hodgkin lymphoma

FA 391

11

Non-Hodgkin lymphoma

FA 392

12

Leukemias

FA 394

13

Chemo-Tax man

FA 407