Hematology 3.1

Question 1

When compared with mature erythrocytes, reticulocytes

A) are larger and bluer on Wright stain from remnant ribonucleic acid (RNA).
B) are larger and have more vacuoles on Wright stain from remnant deoxyribonucleic acid (DNA).
C) stain pinker with new methylene blue.
D) still have a nucleus.

Answer 1

A) are larger and bluer on Wright stain from remnant ribonucleic acid (RNA).

Question 2

Which of the following has a pyknotic nucleus?
A) pronormoblast
B) basophilic normoblast
C) polychromatophilic normoblast
D) orthochromic normoblast

Answer 2

D) orthochromic normoblast

Question 3

What is the fate of erythrocytes when anaerobic metabolic enzymes are reduced in concentration or absent?
A) destruction by the liver
B) destruction by monocytes in the blood
C) hemolysis
D) destruction by complement

Answer 3

C) hemolysis

Question 4

Depletion of serum haptoglobin indicates
A) decreased erythropoiesis.
B) extravascular hemolysis.
C) intravascular hemolysis.
D) increased phagocytosis of macrophages.

Answer 4

C) intravascular hemolysis.

Question 5

The principle energy source for mature red blood cells (RBCs) is
A) the Krebs cycle.
B) the hexose monophosphate pathway.
C) ATP generated from anaerobic glycolysis.
D) adenosine diphosphate (ADP) generated from aerobic glycolysis.

Answer 5

C) ATP generated from anaerobic glycolysis.

Question 6

What stimulates production of erythropoietin?
A) decreased red cell number in the bone marrow
B) increased peripheral red cell number
C) decreased iron stores
D) decreased oxygen level in tissue

Answer 6

D) decreased oxygen level in tissue

Question 7

What components of the erythrocyte membrane are responsible for its negative charge and are also blood group antigens?
A) peripheral proteins
B) cholesterol
C) cation pumps
D) transmembrane proteins

Answer 7

D) transmembrane proteins

Question 8

What important function does 2,3-BPG perform?
A) maintains iron in the hemoglobin molecule in the ferrous state
B) prevents oxidative injury to the red cell
C) facilitates the delivery of oxygen to tissue
D) aids in the exchange of membrane lipids with lipids in plasma

Answer 8

C) facilitates the delivery of oxygen to tissue

Question 9

The breakdown products of heme go through several biochemical degradations to form
A) bilirubin.
B) protoporphyrin.
C) amino acids.
D) haptoglobin.

Answer 9

A) bilirubin.

Question 10

Which of the following is most responsible for the strength and pliancy of the red cell membrane?
A) glycophorin A
B) spectrin
C) cholesterol
D) ankyrin

Answer 10

B) spectrin