Hematology Flashcards
1
Q
Labs in DIC
A
Thrombocytopenia High PT and PTT Low fibrinogen Raised FDP and D-dimer Hemolytic anemia Reduced protein C and S and antithrombin
2
Q
The most important aspect in treating DIC?
Supportive by?
A
Treat the underlying cause (usually sepsis)
Supportive by FFP, cryoprecipitate and platelets)
3
Q
Pathophysiology of DIC?
A
Purpura fulminans
And Microvascular thrombosis
4
Q
Factor V Leiden pathophysiology ?
A
Resistant to degradation by protein C
5
Q
Acquired disorders of thrombosis?
A
Catheter related DIC Plolycythemia (due to CHD) Hypernatremia Malignancy SLE and APS
6
Q
Clues for red cell aplasia?
A
Low retics
Absent red cell precursors
Normal bilirubin and negative Coombs
7
Q
DBA caused by ?
Abnormal features?
A
Mutation in Ribosomal protein genes
80% sporadic
Short stature and abnormal thumbs
