Infection And Immunity Flashcards
PCP prophylaxis ?
Cotrimoxazole
Antibiotic prophylaxis of choice to prevent recurrent bacterial infx?
Azithromycin
Non infectious meningitis is caused by?
Malignancy
Autoimmune
TB meningitis affect which age group
Under 5
Bacterial meningitis pathophysiology?
Host immune response to infection. Not form the organism
Hydrocephalus in meningitis caused by?
Vasculopathy causing infarction and fibrin deposits blocking CSF resorption by arachnoid vilii
In which case of bacterial meningitis there is predominant lymphocytes?
Lyme
In which viral meningitis you have low glucose?
Enteroviral meningitis
How to decrease the risk of long term complications post meningitis like deafness ?
Dexamethasone with ABX
Complications post meningitis include
1• Deafness(cochlear hair cells)
2• Local vasculitis causing CN palsies)
3•Local infarctions predisposing to seizures and epilepsy
4•Subdural effusion
5•Noncommunicating hydrocephalus ( firbin) or communicating blocking cerebral aqueduct
6•Cerebral abscess
When to suspect abscess post Meningitis ?
Condition deteriorates
Space occupying lesion signs
Temperature will continue to fluctuate
Confirm with CT or MRI
Prophylactic with what is required to eradicate nasopharyngeal carriage for household in meningococcal and Hib
When is it not required?
Rifampcin or ciproflaxin
If patient was treated with 3rd cephalosporin
What is helpful in partially treated meningitis ?
High WBC in csf (but culture negative)
Rapid antigen screen and PCR
Treatment of HSV encephalitis and why?
3 weeks of acyclovirbecaisevif shorter course replapses are common
Panton valentine leukocidin producing s. Aures causes?
Necrotizing fasciitis and necrotizing hemorrhagic pneumonia
Plus venous thrombosis
