Endocrine Flashcards
What is the predominant fetal thyroid?
Reverse T3 which is inactive
What happens to TSH after birth?
Surge causing high t3,4
Preterm infants have which T is low?
T4
Why screen congenital hypothyroidism ?
A preventable cause of severe learning difficulties
The most common cause of sporadic congenital hypothyroid ?
Maldescent or athyrosis
The most common cause of congenital hypothyroidism worldwide?
Iodine deficiency’s
Prevented by iodination of salt
When to suspect TSH deficiency as the cause of hypothyroid ?
When there is decrease GH, GRH, ACTH deficiency manifestied in
Hypoglycemia
Micropenis
Undescended testis
Treatment with thyroxine should start when??
Before 2/3 weeks of age to reduce impairment of neural development
Who has the risk of autoimmune hypothyroiditis and other autoimmune disorder?
Down and turners
Biochemical findings in hyperthyroidism ?
Thyroid stimulating immunoglobulin causing the disease
Anti thyroid Peroxisomal antibodies may also be present then causing hypothyroid by trying to resolute the hyper
Treatment of hyperthyroid?
Carbimazole or propylthiouracil
Side effect of anti thyroid and when to screen?
Neutropenia
If develops sore throat and high fever
Symptomatic relief of anxiety tremor and tachycardia by?
Beta blockers
If relapse after 2 years of medication, treatment option include?
Second corse of medications or radioiodine treatment
Subtotal thyroidectomy surgery
Functions of parathyroid hormone
1 bone formation via osteoblasts
2 when Ca is low bone resorption via osteoclasts
3 increases renal uptake of Ca
Activated metabolism of vitamin D to promote gut absorption of Ca
