Hematolologic disorders

Question 1

What is the primary site of hematopoiesis in the body?

Answer 1

Red bone marrow

Question 2

Which hormone primarily regulates erythrocyte production?

Answer 2

Erythropoietin

Question 3

What nutrient is NOT essential for hematopoiesis?

Answer 3

Vitamin D

Question 4

Epoetin alfa is used to treat anemia in patients with which condition?

Answer 4

Chronic renal failure

Question 5

What is a common adverse effect of epoetin alfa therapy?

Answer 5

Hypertension

Question 6

Why is darbepoetin alfa preferred over epoetin alfa?

Answer 6

It has a longer duration of action

Question 7

Which of the following drugs is a granulocyte colony-stimulating factor (G-CSF)?

Answer 7

Filgrastim

Question 8

Filgrastim is primarily used to increase the production of which type of cell?

Answer 8

Neutrophils

Question 9

What is a serious potential adverse effect of filgrastim?

Answer 9

Leukocytosis

Question 10

Oprelvekin is functionally equivalent to which cytokine?

Answer 10

Interleukin-11

Question 11

The primary adverse effect of oprelvekin is what?

Answer 11

Fluid retention

Question 12

Romiplostim and eltrombopag are used to treat which condition?

Answer 12

Chronic immune thrombocytopenic purpura

Question 13

What type of anemia is characterized by large abnormally shaped erythrocytes?

Answer 13

Macrocytic anemia

Question 14

A common cause of vitamin B12 deficiency is the absence of what?

Answer 14

Intrinsic factor

Question 15

What is the effect of anemia on exercise tolerance ?

Answer 15

Decrease

Question 16

The most common antianaemic drugs include cyanocobalamin, folic acid and what other supplement?

Answer 16

Iron supplements

Question 17

Vitamin B12 deficiency can lead to which type of anemia?

Answer 17

Megaloblastic anemia

Question 18

Which of the following is a purified form of vitamin B12?

Answer 18

Cyanocobalamin

Question 19

Iron is essential for the function of which cellular component?

Answer 19

Mitochondrial enzymes

Question 20

A common adverse effect of iron supplements is what?

Answer 20

Constipation

Question 21

Which iron supplement is often used in the treatment of iron deficiency anemia?

Answer 21

Ferrous sulfate

Question 22

Hematopoietic drugs may be used in cancer patients to boost what?

Answer 22

Blood cell counts

Question 23

Why is epoetin alfa not beneficial when anemia is caused by the malignancy itself?

Answer 23

It has no effect on cancer cells

Question 24

Filgrastim is used in patients with cancer to reduce the risk of what?

Answer 24

Infection by increasing neutrophils

Question 25

Blood doping with epoetin alfa increases what?

Answer 25

RBCs and Hgb oxygen-carrying capacity

Question 26

What is a potential risk of blood doping?

Answer 26

Thrombosis

Question 27

Newer drugs used for blood doping are undetectable by current tests.

Answer 27

True

Question 28

Thrombopoietin is produced by which organ?

Answer 28

Liver

Question 29

Colony-stimulating factors are used to treat which condition?

Answer 29

Neutropenia

Question 30

The hormone that controls megakaryocyte activity is what?

Answer 30

Thrombopoietin

Question 31

Iron is absorbed primarily in which part of the intestine?

Answer 31

Duodenum

Question 32

Which protein is responsible for storing iron in the body?

Answer 32

Ferritin

Question 33

What is the function of hepcidin in iron metabolism?

Answer 33

Decrease iron absorption

Question 34

Megaloblastic anemia is most commonly caused by a deficiency in which nutrients?

Answer 34

Vitamin B12 or folic acid

Question 35

Which symptom is specific to vitamin B12 deficiency anemia and not folic acid deficiency anemia?

Answer 35

Neurological symptoms

Question 36

The Schilling test is used to diagnose which type of anemia?

Answer 36

Vitamin B12 deficiency anemia

Question 37

Pegfilgrastim differs from filgrastim in having what advantage?

Answer 37

Longer half-life

Question 38

Sargramostim is a granulocyte-macrophage colony-stimulating factor (GM-CSF) used to increase the production of which cells?

Answer 38

Neutrophils and macrophages

Question 39

Colony-stimulating factors are indicated for use in which condition?

Answer 39

Chemotherapy-induced neutropenia

Question 40

Which erythropoiesis-stimulating agent has a longer half-life allowing for less frequent dosing?

Answer 40

Darbepoietin alfa

Question 41

Epoetin alfa is contraindicated in patients with which condition?

Answer 41

Uncontrolled hypertension

Question 42

What is a potential risk associated with the use of erythropoiesis-stimulating agents?

Answer 42

Hypertension

Question 43

Blood doping is intended to increase what in athletes?

Answer 43

Red blood cell mass

Question 44

One major health risk associated with blood doping is what?

Answer 44

Thromboembolism

Question 45

Which of the following is NOT a method used in blood doping?

Answer 45

High-altitude training

Question 46

Which thrombopoietic agent is used to stimulate platelet production in patients with chronic immune thrombocytopenia?

Answer 46

Eltrombopag

Question 47

A common side effect of eltrombopag is what?

Answer 47

Liver toxicity

Question 48

Romiplostim mimics the action of which hormone?

Answer 48

Thrombopoietin

Question 49

Which drug is used to treat chronic myeloid leukemia (CML)?

Answer 49

Imatinib

Question 50

Rituximab is a monoclonal antibody used to treat which type of lymphoma?

Answer 50

Non-Hodgkin's lymphoma