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BMS 2 > Hematopoesis > Flashcards

Hematopoesis Flashcards

(53 cards)

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1
Q

aplastic anemia

A

difflymphocytes attack bone marrow stem cells

only fat and storm left

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2
Q

blood/components

A

bottom to top

  • rbc
  • buffycoat-wbc/platelets
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3
Q

difference between appearance of myeoblast cells

A

bsopihl-all dark

neutrophil-several uncle

esoinopihl-darker but not as dark as basophil

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4
Q

neutrophil function

A

phago cytose invading bacteria

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5
Q

eosinophil

A

destroy large parasite

-allergic respinse

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6
Q

basohpil

A

release histamine

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7
Q

monocyte

A

become macropages-digets micros and foregone bodies and old cells

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8
Q

which cells are continuously made

A

bone marrow-as long as have stem cells will be good-can even inject if don’t have (as long as no immune incompatibility)
-get around by using synergistic litter mate

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9
Q

syngenic

A

genetially indetical

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10
Q

blood production

A

bony trabecular-large red material-glowing blood precursor

multinucleate cells-megakaryocte-platelet producing cells

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11
Q

CD34

A

on surface of blood stem cells

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12
Q

neoplasia

A

failure to differentiate or undergo pop

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13
Q

senescne

A

deterioration with age

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14
Q

progeinitor

A

committed stem cells can only differentiate into this

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15
Q

what kind of stem cells are bone marrow

A

polurpotent or committed progenitor-takes more time to become pluripotent?

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16
Q

Stochastic vs hierarchicial

A

sot-cells are same and each division yields either 2 fully differentiated cells, 2 progenitorsrs, or one of each

heriarchical-stem makes progenitors which then become differentiated
-with each step in maturation-less ability to replicate until nucleus becomes incapable

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17
Q

blood stem cell surface characteristics

A

cd34

  • got by flow cyto/immunocyto
  • ckit positve and lin negative (lineage)
  • lin has to do wit maturity
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18
Q

flow cyto

A

measures na danlyzes multiple charactersitcs of particles

-add floruest dyte to antibody-identify patroller cell (that has that antibody)

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19
Q

diseases of hemopoietic progenitor cell

A

either granulates or rbis not maturing

-show stem cells ar real

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20
Q

hemapoesis throughout life

A

early occur in gold sac, then move to liver, then to bone marrow

occurs in niche

Long bones make slightly les than flat
-less made in adult then young-but not alot

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21
Q

medularry areas of bones

A

nurturing environemnt to support growth and proliferation-this is niche

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22
Q

bone niche

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A

maintenance of long term quiescence of hemopoietic stem cells in appropriate numbers for blood cell homeostasis

-site for receptor ligand combos between stem and supporting stream cells to support bone niche

23
Q

vascular niche

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A

proliferation of hemopoietic stem cells-their differ nation into mature blood cells and delivery to circulation

24
Q

cxcl4

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A

when inhibited by antibody-litertes stem cell into general circulation

chimokine-substance elaborated by local cells attracting specific other cells

25
bone structure
near endostium and around sinusoids-swhere stem cells formed inner bone-osteobalsts, macrophages
26
stem cell state
quiescent-divdies enough to maintain population but not mature -the more claim the more stem cell maintenence
27
why does hemopoiesis only occur in niche
cell cell signals factors secreted here help-chemical interactions cells here promote HSC maintencen by regulating function of third party cells-other proteins really just bone marrow micro environment
28
runx gene + what would mutant be lie
allows for osteobast formation | -mutant-no hemopoesis inbone marrow-only in yolk sac
29
CBF bta
allows hemopoiesis in fetal liver
30
Runx and CBF complexes
activates and repspresses trx of key regulatory of growth, survival, differentiation pathways absence in these genes cause blood production failure or leukemia
31
Formed elements in blood production
formed elects-rbc/wbc/platelets constant turnover-must react to rapid changes in environment
32
Kit interaction (3 things it does) and mechanism
ligand for kit is on stromal cell involved with hemopoietic stem cell maintenance allows for stem cells to go to correct place allows for mature stem cells to be i nporper number ensure that cd34 positive stem cels are insufficient to restore bone marrow (need kit in addition to cd34 stem cells)
33
sl locus w losuc
where ckit ligand is encoded where ckit is encoded
34
what does homeless require reading cell and stormal cells
need direct cell contact | -need both or else will not have hemopoiesis
35
stratgetic reserve
strategic reserve of stem cell in niche-make sure don't rn out because when begin maturation they will lose ability to proliferate
36
maturation of progenitors (not stem cells)
do not require tight niche contact like stem cells do
37
growth of cells in suspensin - what is required - what determines what grows
require presence of growth promoting factors-need cytokines and interleukins factors introduced-appropoirate cytokines or interleukins
38
interleukin 3 creates
eryhtocytes, mono, mega, granulo
39
CSF creates
colonies of macro and granulocytes colony stimulating factor
40
eryhthropoietin
produced by vascular endothelium in kineys | -example of cytosine
41
how does each colony arise
from a single progenitor cell
42
how do blood cells exist in tissue semisolid agar
remain in suspension slow down movement-but still in suspension -allows to see CFUs/progenitors
43
Hematopoietic growth factors 3 defineition
bind to hemoatopoeitin recepotrs -cytokines-substances that induce growth bind to kinase receptors - c-kit - keep cells in niche - surface recognizeing receptors interleukins-produced by leukocyytes- affect function of leukocytes hematopoietns-hormone like substances which act in endocrine (one organ affecting other), paracrine (one cell affecting other), or autocrine manner
44
cytokine binding
TF (usually for growth) binds to cell membrane recptor with low affinity, then becomes attracted and binds to high affinity receptor-gnerates growth signal
45
4 erythropoiesis steps and what stimulates this
cells get smaller cyto changes nucleous/cyto ratio falls nucelus removed eryothropoiten
46
erythropoiten
incdueces JAK/STAT dimerization - epo is ligand - results in events that enhance growth/suppress apop
47
monocytes
macrophages in tissue phagocytose baceria, fungus, turmor etc. - release cytokines-mediators of inflammation, presents antigen to lymph - may become macrophage
48
thrombopoeises
platelet fomration megakaryocyte (large and 16 nuclei) - platelets form by budding - stimulated by prothrombin-stim production/activation of platelets
49
granulopoiesis
each stage allows cell to become less able to proliferate-more capable of effector function -precursors are able to be seen in biopsy/bone marrow -CSFGM and CSF G-important growth factors
50
cd34
context critical-on myelomonocyte progenitor | -can result in monocle or promyeloyte
51
cd14
associated with monocytes
52
pathway of hieracrcy
myelooid stem cell - myloblast>basophil, eosinophil, neutrophil - monocyte - megakaryocyte>platelets - pronomoblast-erythrocyte lymphoid stem cell-lymphocyte
53
colony forming unit
CSF and colonies produced are measured as BFU -measured when progenitor cells are stimulated in system to produce colonies of granulocytes or macrophages shows that progenitors can grow in vitro with specific factors instead of in niche

BMS 2 (41 decks)

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