Flashcards in Hematopoietic I Deck (13):
reduced O2 carrying capacity, decreased RBC, blood loss. increased turnover with decreased production
mechanistic types of anemia
blood loss, hemolytic, impaired RBC production
Morphologic RBC classification
normocytic/normochromic, mycrocytic/hypochromic, macrocytic hyperchromic
anemia compensation mechanism
hyperplasia of erythroid precursors
increased RBC destruction, elevated reticulocytes/ erythroid hyperplasia. intrinsic or extrinsic
intrinsic, hyper chromatic, "well jolly" stable but not deformable cells. reduced RBC lifespan can remove spleen.
sickle cell anemia
abnormal global synthesis, intrinsic, microvascular obstruction> infarction, spleen! HBS instead of HbA- polymerize
bite cells after crossing spleen. X linked recessive, more damage from oxidation stress.
deficient globin synthesis leads to deposits in bone and increased bone marrow expansion. "crew cut skull"
iron deficient anemia
diminished erythypoeisis. microcytic hypo chromic. Low iron> low heme synthesis.
b12/ folate deficient anemia
diminished erythypoeisis. GI issues, pregnancy folate demands. DNA synthesis issue, neurological issues only present in B12~
hypo cellular marrow- fat cells crowed out. Stem cell issue, also T cells attack bone marrow.