Hematopoietic I Flashcards Preview

Pathology Exam 4 > Hematopoietic I > Flashcards

Flashcards in Hematopoietic I Deck (13):
1

anemia

reduced O2 carrying capacity, decreased RBC, blood loss. increased turnover with decreased production

2

mechanistic types of anemia

blood loss, hemolytic, impaired RBC production

3

Morphologic RBC classification

normocytic/normochromic, mycrocytic/hypochromic, macrocytic hyperchromic

4

anemia compensation mechanism

hyperplasia of erythroid precursors

5

hemolytic anemia

increased RBC destruction, elevated reticulocytes/ erythroid hyperplasia. intrinsic or extrinsic

6

hereditary spherocytosis

intrinsic, hyper chromatic, "well jolly" stable but not deformable cells. reduced RBC lifespan can remove spleen.

7

sickle cell anemia

abnormal global synthesis, intrinsic, microvascular obstruction> infarction, spleen! HBS instead of HbA- polymerize

8

G6d deficiency

bite cells after crossing spleen. X linked recessive, more damage from oxidation stress.

9

thalassemia

deficient globin synthesis leads to deposits in bone and increased bone marrow expansion. "crew cut skull"

10

iron deficient anemia

diminished erythypoeisis. microcytic hypo chromic. Low iron> low heme synthesis.

11

b12/ folate deficient anemia

diminished erythypoeisis. GI issues, pregnancy folate demands. DNA synthesis issue, neurological issues only present in B12~

12

aplastic anemia

hypo cellular marrow- fat cells crowed out. Stem cell issue, also T cells attack bone marrow.

13

bite cells/heinz bodies are in what type of anemia?

G6PD deficiency