Heme Flashcards
(50 cards)
Tx thalassemia (2)
Folic acid, hydroxyurea
Iron studies in anemia of chronic disease
Low iron, low transferrin, high ferritin
Dx hereditary spherocytosis
osmotic fragility test
Which diagnosis? Anemia, thrombocytopenia, and neurologic symptoms
TTP
Which diagnosis? Anemia, mild thrombocytopenia, AKI
HUS
Which diagnosis? Intra-erythrocytic parasites
Babesiosis, Malaria
Reason for newborn screening for sickle cell disease
Prophylactic PCN x5 years (prevent pneumococcal disease)
Most common cause of death in SCD
Acute chest syndrome
Tx of sickle cell anemia (2)
folate, hydroxyurea
Tx of SCD CKD (2)
EPO, ACEI
Severe cause of ITP
IIB/IIIA Inhibitors (Abciximab, eptifibatide, tirofiban)
Screening for what disease is indicated in ITP?
HIV
First-line tx of ITP
glucocorticoids or IVIG
Indications for ITP treatment (3)
Plt <10,000; active bleeding; Plt <50,000 and new dx
Which disease? Antibodies to ADAMTS13 protein
TTP-HUS
Tx TTP-HUS
Plasma exchange/glucocorticoids in severe cases
Which diagnosis? hypocellularity with increased fatty deposits on bone marrow biopsy
Aplastic anemia
Tx aplastic anemia (3)
HSCT, Cyclosporine, anti-thymocyte globulin
Dx AML
> 20% blasts on bone marrow biopsy
APML mutation
t(15;17)/RAR
Tx AML (2)
idarubicin, cytarabine
Mutation in polycythemia vera
JAK2
Tx of polycythemia vera
Phlebotomy
Mutation in CML
t(9;22)/BCR-ABL
