Heme Flashcards

(30 cards)

1
Q

Causes of micro, normo, macrocytic anemia

A

Microcytics: TICS
Normocytic: chronic dz, hemolytic
Macrocytic: B12, folate

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2
Q

This anemia will not respond to epo

A

Chronic dz

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3
Q

Target cells, Howell-Jolly bodies

A

Sickle-cell

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4
Q

Smooth tongue, glossitis, cheilosis

Stocking-glove paresthesia, loss of sensation, ataxia

A

B12 deficiency

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5
Q

Pernicious anemia

A

Cannot absorb B12 (lack intrinsic factor)

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6
Q

Triggered by drugs, infxn, fava beans

Bite cells, Heinz bodies

A

G6PD deficiency anemia

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7
Q

Tx for G6PD def anemia

A

Self-limiting episodes

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8
Q

Auer rods

Adults

A

AML

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9
Q

Kids
Pancytopenia
Bone pain

A

ALL

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10
Q

AML tx

A

Chemo + radiation/drugs

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11
Q

ALL tx

A

Chemo + radiation/drugs (50% cure)

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12
Q

Smudge cells

Older pts

A

CLL

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13
Q

Philadelphia chromosome

Young to middle aged

A

CML

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14
Q

CLL tx

A

Often harmless, but resistant to cure

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15
Q

CML tx

A

Gleevac, bone marrow transplant

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16
Q

Associated w/ EBV
Pain in node after alcohol
Reed-Sternberg cells

A

Hodgkin lymphoma

17
Q

Painless lymphadenopathy

A

Non-Hodgkin lymphoma

18
Q

Cancer of plasma cells
Rouleaux formation (RBC stack like coins)
Monoclonal spike
Bence Jones proteins in urine

A

Multiple myeloma

19
Q

Gingival bleeding

A

Von Willebrand

20
Q

Von Willebrand tx

21
Q

Vit K dependent clotting factors

A

Factors 2, 7, 9, 10

22
Q

Factor 8 def, X-linked (males)

23
Q

Factor 9 def, X-linked (males)

24
Q

Factor V Leiden: clotting or bleeding d/o?

25
Protein C & S deficiency: clotting or bleeding d/o?
Clotting d/o, C & S are natural anticoags
26
Unopposed conversion of fibrinogen to fibrin
Antithrombin III deficiency
27
Autoimmune, excessive platelet destruction | Follows viral infxn (1-4 wks later)
Idiopathic thrombocytopenic purpura
28
Def of enzyme needed to cleave vWF | Schistocytes (RBC fragments)
Thrombotic thrombocytopenic purpura
29
Idiopathic thrombocytopenic purpura tx
Self-limiting
30
Thrombotic thrombocytopenic purpura tx
Plasma exchange, prednisone, antiplatelets