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Hematalogy Lecture > Heme Exam C > Flashcards

Heme Exam C Flashcards

1
Q

Aplastic anemia if RPI is…

A

<2

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2
Q

How do you calculate RPI?

A

Retic % x [Hct./45]

divided by

maturation time in days

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3
Q

HJ is seen in ____________anemia.

A

megaloblastic

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4
Q

Warm Auto, which cell is seen?

A

spherocytes

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5
Q

Cold Auto will have which cells?

A

spherocytes and schistocytes

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6
Q

Osmotic fragility with thalassemia?

A

decreased

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7
Q

Which test is not important to differentiate IDA and thalassemia?

A

OF,SI,Sfe

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8
Q

What is associated with babies with kidney disease?

A

HUS

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9
Q

CD marker for PNH?

A

16, 48, 55, 59

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10
Q

Acute Acquired Red Cell Aplasia is usually following a ______ infections, in which some viruses attack the erythroblasts

A

viral

-There is no need for any treatment, as it is cleared along with the virus

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11
Q

:genetic and is usually manifested in infants below the age of
one, they have similar characteristics of Fanconi’s anemia such as microcephaly, short stature, skeletal deformities

A

Diamond Blackfan Syndrome

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12
Q

What is the diagnostic test for Diamond Blackfan Syndrome?

A

an enzyme assay for Adenosine deaminase

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13
Q

Does IDA or ACD have a high RDW?

A

IDA

-ACD is fairly normal (due to sufficient iron stores)

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14
Q

What is TIBC with IDA?

A

normal or increased

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15
Q

What is TIBC with ACD?

A

normal or decreased

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16
Q

measures iron in…plasma/serum
-the Fe3+ form of iron that is bound to the transport protein transferrrin in the plasma

A

Serum iron

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17
Q

What lab values are associated with sideroblastic anemia?

A

-SI increased
-TIBC decreased or normal
-Prussian blue for pappenheimer inclusions
- >10% sideroblasts in the BM
-These are the siderotic granules ppt, due to not proper iron being put into the heme. They are Fe3+ form. ( insoluble)

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18
Q

___% of iron in the body is the form of hemoglobin

A

70

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19
Q

EPO in intravascular hemolysis is…

A

increased

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20
Q

Hgb that has FE3+ and 1% in adult

A

Methemoglobin

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21
Q

What the normal adult hemoglobin?

A

-

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22
Q

What is the normal fetal hemoglobin?

A

-

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23
Q

Which pathway removes oxidative stress?

A

hexose monophosphate

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24
Q

Which changes methemoglobin to hemoglobin?

A

hexose monophosphate

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25
Q

Iron that binds to hemoglobin is in what state?

A

ferrous

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26
Q

Intravascular hemolysis –> _________ haptoglobin

A

decreased

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27
Q

iron is stored in the form of soluble _________ and insoluble _________.

A

ferritin, hemosiderin

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28
Q

Normal SI range?

A

50­-170

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29
Q

Normal TIBC range?

A

250-450

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30
Q

Normal Se Ferritin range?

A

10-120

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31
Q

KB stain is for

A

alpha2 gamma2

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32
Q

Erythropoietin will stimulate which CFU?

A

CFU-E

33
Q

Intravascular hemolysis is characteristic of which cell/cells?

A

?

34
Q

Pernicious anemia is not a B12 deficiency its an _________ problem.

A

intrinsic factor

35
Q

How are dacrocytes formed?

A

when the cells attempt to pass through the microcirculation resulting in the pinching the cell as the part containing the inclusion is left behind.

36
Q

what crystals is associated with nephrotic syndrome

A

cholesterol crystals

37
Q

Will RDW be increased or decreased with IDA?

A

increased

38
Q

Beta thalassemia has decreased hgb A and increased hgb ____ and hgb ____

A

A2, F

39
Q

urobilinoginurua , hemoglobinuria and hemosiderinuria are characteristic of which hemolysis?

A

intravascular

40
Q

45% hgb S and 46% hgb C is characteristic of what disease?

A

Hemoglobin S/C disease

41
Q

Which thalassemia has the MOST codocytes?

A

Beta major???

42
Q

CRC formula

A

reticulocyte % × (patient Hct/normal Hct)

43
Q

What is the difference between polychromatic cells and reticulocytes?

A

Polychromasia and reticulocytes are the same cell with wright and supravital stain respectively

44
Q

Valine for glutamic acid is hgb ___

A

S

45
Q

Lysine for glutamic acid if hgb ___

A

C

46
Q

hypersegmented neutrophils is seen in what type of anemia?

A

megaloblastic anemia

47
Q

Malaria dugs can cause what deficiency?

A

G6PPD

48
Q

Ture or false: All polychromatophilic cells are reticulocytes

A

true

49
Q

Hemoglobinpath. Vs thal.

A

Thal = decreased rate of SYNTHESIS
Hgb = DNA Mutation and structure

50
Q

What is the last stage of erythrocyte maturation that is capable of mitosis?

A

Polychromatic erythroblast

51
Q

what is the order of RBC maturation?

A

-pronormoblast
-basophilic normoblast
-polychromatic normoblast
-orthochromic
-polychromatic
-erythrocyte

52
Q

IDA vs ACD - ferritin

A

IDA- low
ACD- normal or increased

53
Q

CBC w/ increased MCV and increased total bilirubin and LDH…what test should be ordered next?

A

B12 folate DNA synthesis testing

54
Q

LD with IgM that binds to complement

A

PCH

55
Q

Cooley Anemia is another name for…

A

Beta Thal. Major

56
Q

yellow crystals in macrophages?

A

Bilirubin crystals

57
Q

Kidneys stone type seen in children

A

Calcium stones (oxalate and phosphate)

58
Q

Serum FA-ABS pos and VDRL CSF neg, what does it mean?

A

neurosyphillis

59
Q

Melituria is due to…

A

sugar in the urine

60
Q

glucosuria and acidic urine is associated with…

A

DM

61
Q

Severe intrinsic hemolytic anemia will have what change

A

decreased haptoglobin

62
Q

Guthrie test control

A

Bactillius subtilis is incubated on a media of known blood concentration

63
Q

what is the most common cause of end stage renal disease?

A

Diabetic nephropathy

64
Q

What is the relative protein concentrations between CSF and serum?

A

concentration is much lower in CSF!

65
Q

What is the normal amount of CSF in an adult?

A

around 140 mL

66
Q

An athlete is training and his increase/decrease 2,3BPG will cause an increase/decrease to his hemoglobin’s affinity for oxygen

A

Increase in 2,3BPG will decrease Hgb O2 affinity and increase O2 offloading to the tissues

67
Q

Normal CSF protein and glucose levels?

A

15–40 mg/dL protein
50–80 mg/dL (two thirds of blood glucose)

68
Q

What disease causes large amounts of branched-chain amino acids to be excreted in the urine?

A

Branched-chain α-ketoacid dehydrogenase deficiency, commonly known as Maple Syrup Urine Disease (MSUD),

69
Q

megaloblastic anemia is associated with what inclusions?

A

HJ bodies

70
Q

-Lithotripsy is a procedure that…

A

uses shock waves to break up stones in the kidney

71
Q

What are Cabot rings composed of?

A

remnants from mitotic spindles

72
Q

Which organic acidemia produces urine with an odor of “sweaty feet”?

A

Isovaleric acidemia

73
Q

Abnormal amounts of indigo blue in the urine are indicative of a defect in the metabolism of

A

Tryptophan

74
Q

The finding of increased amounts of the serotonin degradation product 5-HIAA in the urine indicates:

A

Argentaffin cell tumors

75
Q

Renal tubular epithelial cells and casts are significant for what condition?

A

Acute tubular necrosis

76
Q

Analysis of urine from an infant whose mother reported a blue staining on the diapers showed increased levels of indican and a generalized aminoaciduria. On the basis of these findings, the infant was diagnosed as having:

A

Hartnup disease

77
Q

The finding of a “blue diaper” is indicative of a defect in the metabolism of:

A

Tryptophan

78
Q

What is the last stage in erythropoiesis that can Undergo mitosis and divide

A

Polychromatophilic normoblast

79
Q

a hemolytic disorder caused by Donath Landsteiner IgG autoantibody that binds to red cells in the cold, and causes hemolysis of the cells when complement activated at warmer temperatures

A

PCH

Hematalogy Lecture (35 decks)

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