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Hematalogy Lecture > Heme Exam C > Flashcards

Heme Exam C Flashcards

(79 cards)

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1
Q

Aplastic anemia if RPI is…

A

<2

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2
Q

How do you calculate RPI?

A

Retic % x [Hct./45]

divided by

maturation time in days

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3
Q

HJ is seen in ____________anemia.

A

megaloblastic

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4
Q

Warm Auto, which cell is seen?

A

spherocytes

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5
Q

Cold Auto will have which cells?

A

spherocytes and schistocytes

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6
Q

Osmotic fragility with thalassemia?

A

decreased

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7
Q

Which test is not important to differentiate IDA and thalassemia?

A

OF,SI,Sfe

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8
Q

What is associated with babies with kidney disease?

A

HUS

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9
Q

CD marker for PNH?

A

16, 48, 55, 59

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10
Q

Acute Acquired Red Cell Aplasia is usually following a ______ infections, in which some viruses attack the erythroblasts

A

viral

-There is no need for any treatment, as it is cleared along with the virus

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11
Q

:genetic and is usually manifested in infants below the age of
one, they have similar characteristics of Fanconi’s anemia such as microcephaly, short stature, skeletal deformities

A

Diamond Blackfan Syndrome

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12
Q

What is the diagnostic test for Diamond Blackfan Syndrome?

A

an enzyme assay for Adenosine deaminase

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13
Q

Does IDA or ACD have a high RDW?

A

IDA

-ACD is fairly normal (due to sufficient iron stores)

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14
Q

What is TIBC with IDA?

A

normal or increased

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15
Q

What is TIBC with ACD?

A

normal or decreased

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16
Q

measures iron in…plasma/serum
-the Fe3+ form of iron that is bound to the transport protein transferrrin in the plasma

A

Serum iron

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17
Q

What lab values are associated with sideroblastic anemia?

A

-SI increased
-TIBC decreased or normal
-Prussian blue for pappenheimer inclusions
- >10% sideroblasts in the BM
-These are the siderotic granules ppt, due to not proper iron being put into the heme. They are Fe3+ form. ( insoluble)

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18
Q

___% of iron in the body is the form of hemoglobin

A

70

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19
Q

EPO in intravascular hemolysis is…

A

increased

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20
Q

Hgb that has FE3+ and 1% in adult

A

Methemoglobin

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21
Q

What the normal adult hemoglobin?

A

-

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22
Q

What is the normal fetal hemoglobin?

A

-

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23
Q

Which pathway removes oxidative stress?

A

hexose monophosphate

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24
Q

Which changes methemoglobin to hemoglobin?

A

hexose monophosphate

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25
Iron that binds to hemoglobin is in what state?
ferrous
26
Intravascular hemolysis --> _________ haptoglobin
decreased
27
iron is stored in the form of soluble _________ and insoluble _________.
ferritin, hemosiderin
28
Normal SI range?
50­-170
29
Normal TIBC range?
250-450
30
Normal Se Ferritin range?
10-120
31
KB stain is for
alpha2 gamma2
32
Erythropoietin will stimulate which CFU?
CFU-E
33
Intravascular hemolysis is characteristic of which cell/cells?
?
34
Pernicious anemia is not a B12 deficiency its an _________ problem.
intrinsic factor
35
How are dacrocytes formed?
when the cells attempt to pass through the microcirculation resulting in the pinching the cell as the part containing the inclusion is left behind.
36
what crystals is associated with nephrotic syndrome
cholesterol crystals
37
Will RDW be increased or decreased with IDA?
increased
38
Beta thalassemia has decreased hgb A and increased hgb ____ and hgb ____
A2, F
39
urobilinoginurua , hemoglobinuria and hemosiderinuria are characteristic of which hemolysis?
intravascular
40
45% hgb S and 46% hgb C is characteristic of what disease?
Hemoglobin S/C disease
41
Which thalassemia has the MOST codocytes?
Beta major???
42
CRC formula
reticulocyte % × (patient Hct/normal Hct)
43
What is the difference between polychromatic cells and reticulocytes?
Polychromasia and reticulocytes are the same cell with wright and supravital stain respectively
44
Valine for glutamic acid is hgb ___
S
45
Lysine for glutamic acid if hgb ___
C
46
hypersegmented neutrophils is seen in what type of anemia?
megaloblastic anemia
47
Malaria dugs can cause what deficiency?
G6PPD
48
Ture or false: All polychromatophilic cells are reticulocytes
true
49
Hemoglobinpath. Vs thal.
Thal = decreased rate of SYNTHESIS Hgb = DNA Mutation and structure
50
What is the last stage of erythrocyte maturation that is capable of mitosis?
Polychromatic erythroblast
51
what is the order of RBC maturation?
-pronormoblast -basophilic normoblast -polychromatic normoblast -orthochromic -polychromatic -erythrocyte
52
IDA vs ACD - ferritin
IDA- low ACD- normal or increased
53
CBC w/ increased MCV and increased total bilirubin and LDH…what test should be ordered next?
B12 folate DNA synthesis testing
54
LD with IgM that binds to complement
PCH
55
Cooley Anemia is another name for...
Beta Thal. Major
56
yellow crystals in macrophages?
Bilirubin crystals
57
Kidneys stone type seen in children
Calcium stones (oxalate and phosphate)
58
Serum FA-ABS pos and VDRL CSF neg, what does it mean?
neurosyphillis
59
Melituria is due to...
sugar in the urine
60
glucosuria and acidic urine is associated with...
DM
61
Severe intrinsic hemolytic anemia will have what change
decreased haptoglobin
62
Guthrie test control
Bactillius subtilis is incubated on a media of known blood concentration
63
what is the most common cause of end stage renal disease?
Diabetic nephropathy
64
What is the relative protein concentrations between CSF and serum?
concentration is much lower in CSF!
65
What is the normal amount of CSF in an adult?
around 140 mL
66
An athlete is training and his increase/decrease 2,3BPG will cause an increase/decrease to his hemoglobin’s affinity for oxygen
Increase in 2,3BPG will decrease Hgb O2 affinity and increase O2 offloading to the tissues
67
Normal CSF protein and glucose levels?
15–40 mg/dL protein 50–80 mg/dL (two thirds of blood glucose)
68
What disease causes large amounts of branched-chain amino acids to be excreted in the urine?
Branched-chain α-ketoacid dehydrogenase deficiency, commonly known as Maple Syrup Urine Disease (MSUD),
69
megaloblastic anemia is associated with what inclusions?
HJ bodies
70
-Lithotripsy is a procedure that...
uses shock waves to break up stones in the kidney
71
What are Cabot rings composed of?
remnants from mitotic spindles
72
Which organic acidemia produces urine with an odor of "sweaty feet"?
Isovaleric acidemia
73
Abnormal amounts of indigo blue in the urine are indicative of a defect in the metabolism of
Tryptophan
74
The finding of increased amounts of the serotonin degradation product 5-HIAA in the urine indicates:
Argentaffin cell tumors
75
Renal tubular epithelial cells and casts are significant for what condition?
Acute tubular necrosis
76
Analysis of urine from an infant whose mother reported a blue staining on the diapers showed increased levels of indican and a generalized aminoaciduria. On the basis of these findings, the infant was diagnosed as having:
Hartnup disease
77
The finding of a "blue diaper" is indicative of a defect in the metabolism of:
Tryptophan
78
What is the last stage in erythropoiesis that can Undergo mitosis and divide
Polychromatophilic normoblast
79
a hemolytic disorder caused by Donath Landsteiner IgG autoantibody that binds to red cells in the cold, and causes hemolysis of the cells when complement activated at warmer temperatures
PCH

Hematalogy Lecture (35 decks)

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