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Integrative Week Two > Heme First Aid > Flashcards

Flashcards in Heme First Aid Deck (86):
1

WBC Differential

N L M E B

2

increased immature neutrophils/band cells

increased myeloid production
- bacterial infection
- CML

3

Causes of Eosinophilia

neoplastic
asthma
allergic processes
CVD
parasites

4

B lymphocyte

humoral immune
bone marrow

5

T lymphocyte

stem cells in bone marrow, matures in thymus
cellular immune response

6

cytotoxic T cells

Cd8
recognized MHC I

7

Helper T cells

express CD4
recognize MHC II

8

Acanthocyte/spur cell

liver disease
abetalipoproteinemia

9

Basophilic stippling

thalassemias
anemia of chronic disease
lead poisoning

10

bite cell

G6PD def

11

elliptocyte

hereditary elliptocytosis

12

Macro-ovalocyte

megoblastic anemia
marrow failure

13

ringed sideroblasts

sideroblastic anemia
excess iron in mitochondria

14

schistocyte/helmet cell

DIC
TTP
HUS
traumatic hemolysis

15

spherocyte

hereditary spherocytosis
autoimmune hemolysis

16

tear drop cell

bone marrow infiltration (myelofibrosis)

17

target cell

HbC disease
Asplenia
Liver disease
thalassemia

18

Heinz body

G6PD def
heinz-body like inclusions with alpha thalassemia

19

Howell-Jolly bodies

functional hyposplenia or asplenia
mothball ingestion/napthalene

20

microcytic, hypochromic anemias

iron def
alpha thalassemia, beta thal
lead poisoning
sideroblastic

21

macrocytic anemia

foltae, b12 def
nonmegaloblastic macrocytic anemias

22

normocytic, normochromic anemias

intravascular, extravascular hemolysis
ACD
aplastic anemia
CKD

23

intravascular hemolysis

increased LDH
hemoglobin in urine

24

extravascular hemolysis

increase LDH plus increased UCB (jaundice!)

25

Paroxysmal Nocturnal Hemoglobinuria symptoms


hemolytic anemia, pancytopenia, venous thrombosis

26

PN Hemoglobinuria cause

increased complement mediated RBC lysis
loss of GPI linked proteins (CD 55/59)

27

Labs for PN Hemoglobinuria

CD 55/ 59

28

Treatment for PN Hemoglobinuria

eculizumab

29

Hereditary Spherocytosis treatment

splenectomy

30

Hereditary Spherocytosis Cause

red cell membrane instability
defect in ankyrin or spectrin

31

G6PD exacerbated by

sulfa drugs
infections
fava beans

32

G6PD genetics

X linked
decreased glutathione
Heinze bodies + bite cells

33

Pyruvate kinase definency

hemolytic anemia in new born

34

autosplenectomy

Howell-Jolly bodies
sickle cell

35

Sickle Cell treatment

hydroxyurea (increases HbF)
BMT

36

Warm agglutinin

IgG
often seen with SLE, CLL, alpha-methyldopa

37

Cold Agglutinin

IgM
seen in CLL, mono, mycoplasma pneuomnia

38

Microangiopathic anemia

schistocytes

39

weird causes of microangiopathic anemia

malignant htn
sle

40

Iron Def Labs

decreasd Iron
increased TIBC/transferrin
decreased ferritin
decreased transferrin saturation (serum iron/TIBC)

41

transferrin saturation

iron/TIBC

42

Chronic disease labs

decreased iron
decreased transferrin/TIBC
increased ferritin

43

Hemochromatosis labs

increased iron
decreased transferrin
increased ferritin
increased transferrin saturation

44

Pregnancy/OCP lab values

increased transferrin/TIBC
decreased transferrin saturation

45

transferrin

transport iron in blood

46

ferritin

primary iron storage protein

47

Hemophilia A

def of VIII
increase PTT

48

Hemophilia B

def of IX
increase PTT

49

Vit K def

decrease synthesis of 2,7,9,10, protein C and S

50

Hodgkin's Lymphoma

associated with EBV
Reed-Sternberg Cells
B signs/symptoms
localized nodes

51

Non-Hodgkin's Lymphoma

multiple, non contiguous nodes
mostly involving B cells
associations with HIV and immunnosuppresion

52

Reed-Sternberg Cells

CD 30+, CD 15+ B cells

53

plasma cells with clock face

Multiple Myeloma

54

ALL

<15 years
often mediastinal mass
increased lymphoblasts

55

Hair Cell Leukemia

B cell tumor in elderly
TRAP positive

56

Hairy Cell Leukemia treatment

cladribine
adenosine analog

57

AML

Auer rods
older onset
DIC common

58

t(9:22)

CML
philadelphia chromosome
bcr-abl

59

t(8:14)

Burkitt's lymphoma
c-myc activation

60

t(11:14)

cyclin D1 activation
mantle cell lymphoma

61

T(14:18)

follicular lymphomas
bcl-2 activation

62

Polycytehmia vera

Jak2 mutation
increased, RBC, WBC, platelets

63

JAK 2 mutation

polycytehmia vera

64

deficient alpha-aminolevulinic acid

lead posioning

65

symptoms of lead poisoning

mental deterioation, sideroblastic anemia

66

anti-GpIIB/IIIa antibodies

ITP

67

increased megakarocytes

ITP

68

ADAMTS 13

vWF metalloprotease
TTP

69

ITP, TPP lab values

increased BT
normal PT, PTT

70

polycythemia symptoms

itching after shower (increased histamine)
ruddy skin
palpable spleen

71

conseuqence of HIT

deep vein and arterial thrombosis

72

Hereditary Angioedema

swelling of eyelids and lips
decrease C1 esterase inhibitor

73

Heparin

anti-coagulant
cofactor for activation of anti-thrombin

74

Warfarin

chronic anti-coag
interferes with synthesis and carboxylation of vit K dependent clotting factors

75

Heparin monitoring

PTT (intrinsic)

76

Warfarin monitoring

PT/INR (extrinsic)

77

Warfarin overdose treatment

IV vitamin K and fresh frozen plasma

78

ribavirin SE

hemolytic anemia

79

Hodgkin's lymphoma treatment

Bleomycin

80

Pacitaxel use

ovarian and breast carcinomas

81

A blood Group

A antigen on RBC
anti-B antibody

82

B blood Group

B antigen
anti-A antibody

83

AB blood group

A, B antigens
no antibodies
universal recipient of RBC
universal donor of plasma

84

O blood group

Anti-A and Anti-B antibodies
universial donor of RBCs
universal recipient of plasma

85

HbH

deletion of three alpha genes
excess Beta globulin forms Beta-4 (HbH)

86

Plummer-Vinson syndrome

iron def anemia
esophageal webs
atrophci glossitis