Endocrine Flashcards

(47 cards)

1
Q

Sulfonylureals (glyburide)

A

hypoglycemia

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2
Q

Amylin analogues (pramlintide)

A

hypoglycemia

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3
Q

Insulin

A

hypoglycemia

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4
Q

Metformin

A

lactic acidosis
don’t use in renal failure
diarrhea

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5
Q

Thiazolidinediones (pioglitazone)

A

CHF/fluid retention

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6
Q

GLP-1 analogues (exenatide)

A

pancreatitis

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7
Q

Grave’s disease

A

exophthalmos
thyroid bruit
diffuse uptake on thyroid scan

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8
Q

Thyroiditis

A

tender thyroid, post URI

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9
Q

Pituitary tumor

A

hyperthyroid

high TSH, T4, T3

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10
Q

surreptitious levothyroxine use

A

hyperthyroid
low uptake on scan
no URI

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11
Q

Placental abruption

A

vaginal bleeding

abdominal pain

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12
Q

Placenta previa

A

painless vaginal bleeding, often 30 weeks

placenta overlies internal cervical os

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13
Q

Placenta accreta

A

severe painless postpartum hemorrhage
previous C-section or previa
placenta villi on myometrium
defect in decidua basalis layer

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14
Q

Uterine Rupture

A

painful massive postpartum hemorrhage

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15
Q

Uterine atony

A

long labor, soft uterus

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16
Q

Sheehan syndrome

A

no lactation
DI after delivery
sometimes shock
per-partum pituitary hemorrhage

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17
Q

post menopausal vaginal bleeding

A

endometrial cancer until proven otherwise

need biopsy

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18
Q

Ectopic pregnancy

A

abdominal pain
LMP 6-8 weeks ago
UPT positive
adnexal mass

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19
Q

preeclampsia

A

severe HTN after 20 weeks gestation
proteinuira, end organ injury
w/ seizures = ecclampsia

20
Q

HELLP Syndrome

A

preeclampsia
low platelets
elevated LFTs
hemolysis

21
Q

post partum complications

A

depression
PE, cardiomyopathy
amniotic fluid embolism

22
Q

Group B strep

A

cloudy amniotic fluid

septic newborn

23
Q

Diabetic Ketoacidosis

A

low glucose
high potassium
pseudohyponatremia/low sodium

24
Q

surreptitious insulin use labs

A

low glucose
low C-peptide
high insulin

25
insulinoma
high C peptide
26
Sulfonylureas MOA
secretagogue | makes pancreas secrete insulin
27
Metformin MOA
reduce hepatic glucose production
28
TZB MOA
decrease insulin resistance
29
Acarbose MOA
reduce glucose absorption | but flatulence
30
Lithium
diabetes insipidus
31
diabetes insipidus
high sodium low urine osm (50-100) lots of urine output
32
causes of high sodium
DI | dehydration
33
olanzapine
antipsychotic | associated with development of diabetes
34
elevated T3, T4, TSH
pituitary tumor producing TSH
35
drugs that can cause high WBC
PTU | sulfa drugs
36
hypothyroidism labs
low T3, T4 | high TSH
37
Low T3, T4, TSH
hypopituitarism | euthyroid sick syndrome
38
Chvotsek sign
hypocalcemia | destruction of parathyroid glands
39
multiple myeloma mechanism
osteoclast activation by cytokines
40
prostate cancer mechanism
osteolytic bone involement by tumor
41
Addison's disease
skin pigmentation - high ACTH orthostatic changes in BP - loss of cortisol, aldosterone low Na high K
42
Adrenal Adenoma
low or high dose dexamethasone doesn't suppress cortisol
43
congenital adrenal hyperplasia
21-hydroxylase
44
hyperaldosteronism
high bp low K, high bicarb, normal Na increased thirst
45
SIADH
low Na euvolemic high urine osmolarity
46
Central Pontine myelinolysis
rapid correction of low Na | dysarthria, dysphagia, paraparesis
47
cocaine
placental abruption