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Integrative Week Two > Endocrine > Flashcards

Flashcards in Endocrine Deck (47):
1

Sulfonylureals (glyburide)

hypoglycemia

2

Amylin analogues (pramlintide)

hypoglycemia

3

Insulin

hypoglycemia

4

Metformin

lactic acidosis
don't use in renal failure
diarrhea

5

Thiazolidinediones (pioglitazone)

CHF/fluid retention

6

GLP-1 analogues (exenatide)

pancreatitis

7

Grave's disease

exophthalmos
thyroid bruit
diffuse uptake on thyroid scan

8

Thyroiditis

tender thyroid, post URI

9

Pituitary tumor

hyperthyroid
high TSH, T4, T3

10

surreptitious levothyroxine use

hyperthyroid
low uptake on scan
no URI

11

Placental abruption

vaginal bleeding
abdominal pain

12

Placenta previa

painless vaginal bleeding, often 30 weeks
placenta overlies internal cervical os

13

Placenta accreta

severe painless postpartum hemorrhage
previous C-section or previa
placenta villi on myometrium
defect in decidua basalis layer

14

Uterine Rupture

painful massive postpartum hemorrhage

15

Uterine atony

long labor, soft uterus

16

Sheehan syndrome

no lactation
DI after delivery
sometimes shock
per-partum pituitary hemorrhage

17

post menopausal vaginal bleeding

endometrial cancer until proven otherwise
need biopsy

18

Ectopic pregnancy

abdominal pain
LMP 6-8 weeks ago
UPT positive
adnexal mass

19

preeclampsia

severe HTN after 20 weeks gestation
proteinuira, end organ injury
w/ seizures = ecclampsia

20

HELLP Syndrome

preeclampsia
low platelets
elevated LFTs
hemolysis

21

post partum complications

depression
PE, cardiomyopathy
amniotic fluid embolism

22

Group B strep

cloudy amniotic fluid
septic newborn

23

Diabetic Ketoacidosis

low glucose
high potassium
pseudohyponatremia/low sodium

24

surreptitious insulin use labs

low glucose
low C-peptide
high insulin

25

insulinoma

high C peptide

26

Sulfonylureas MOA

secretagogue
makes pancreas secrete insulin

27

Metformin MOA

reduce hepatic glucose production

28

TZB MOA

decrease insulin resistance

29

Acarbose MOA

reduce glucose absorption
but flatulence

30

Lithium

diabetes insipidus

31

diabetes insipidus

high sodium
low urine osm (50-100)
lots of urine output

32

causes of high sodium

DI
dehydration

33

olanzapine

antipsychotic
associated with development of diabetes

34

elevated T3, T4, TSH

pituitary tumor producing TSH

35

drugs that can cause high WBC

PTU
sulfa drugs

36

hypothyroidism labs

low T3, T4
high TSH

37

Low T3, T4, TSH

hypopituitarism
euthyroid sick syndrome

38

Chvotsek sign

hypocalcemia
destruction of parathyroid glands

39

multiple myeloma mechanism

osteoclast activation by cytokines

40

prostate cancer mechanism

osteolytic bone involement by tumor

41

Addison's disease

skin pigmentation - high ACTH
orthostatic changes in BP - loss of cortisol, aldosterone
low Na
high K

42

Adrenal Adenoma

low or high dose dexamethasone doesn't suppress cortisol

43

congenital adrenal hyperplasia

21-hydroxylase

44

hyperaldosteronism

high bp
low K, high bicarb, normal Na
increased thirst

45

SIADH

low Na
euvolemic
high urine osmolarity

46

Central Pontine myelinolysis

rapid correction of low Na
dysarthria, dysphagia, paraparesis

47

cocaine

placental abruption