Heme/Onco

Question 1

16 y/o, getting tired lately
Normal TSH
Normal HCT
MCV low
Ovalocytes on Peripheral smear

Test to confirm DX?

Answer 1

B thalassemia Minor!

Order Hg Electrophoresis - HbA2 –> High; HbA –> low

Question 2

Test to establish a diagnosis of Chronic lymphocytic leukemia

Answer 2

Flow cytometry and immunophenotyping of peripheral blood

Question 3

63 y/o with pulmonary nodule of 2 cm on CT

Radiologic Features that can predict Malignancy? (6)

Answer 3

1. > 10mm
2. Upper lung
3. Ground glass
4. No calcification
5. Irregular boarders
6. Increase in size overtime

Malignancy if
Older age
Hx of smoking
Hx of CA