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Flashcards in Hemostasis Deck (15):
1

thrombus

stationary clot on blood vessel wall

2

embolus

clot that detaches from site of origin and travels

3

Coagulation Factor II

Thrombin

4

Describe what occurs in primary hemostasis and what clotting factor is involved, and what is its function. What coagulation tests can be used to assess it?

First, vasoconstriction. Platelet activation, adhesion, and aggregation. Von Willebrand's Factor helps platelet plug adhere.

BMBT

5

Describe secondary hemostasis and name the tests that can assess it

cascade of enzyme conversions lead to the formation of fibrin and the stabilization of the platelet plug.

PT and PTT
(prothrombin time and partial thromboplastin time)

6

Products of fibrinolysis? What performs it, and what is it activated by?

FDP and d-dimers

Tissue Plasminogen Activator
plasminogen -> plasmin

hydrolysis of fibrin. FDP also has anti hemostatic properties

7

where are most clotting factors synthesized? name an exception

the liver

tissue thromboplastin

8

what is factor XIII important for?

stabilizing cross-linked fibrin strands

9

what mineral is important in clotting

calcium

10

describe what happens in the extrinsic pathway

factor VII and tissue thromboplastin (both found in subendothelial adventitial cells) form a complex. "tissue thromboplastin activated factor VII complex". Lead to the activation of factor IX and X

11

what is factor XII associated with? what is it activated by?

assoc with thrombi growth

wet anionic surfaces activate it

12

thrombocyte lifespan?c describe their general appearance

4-6 days

small round to oval anucleated cell fragments (non-mammals have nuclei)

13

thrombocyte precursor?

megakaryocyte

14

normal thrombocyte count?

what would constitute thrombocytopenia?

when would clinical signs of hemorrhaging appear?

200k-500k cells/microliter

<50k cells/microliter

15

normal platelet count for avians?

20-30k cells/microliter