Hepatitis

Question 1

Hbsag becomes undetectable _____ after onset of jaundice

Answer 1

after 1-2 mos

Question 2

When does antiHBc appear in the serum

Answer 2

Within the first 1-2 weeks after appearance of HBsAg

Question 3

HbsAg levels detectable when

Answer 3

Within 1-12 weeks

Question 4

HCV gains entry into the hepatocytes through this receptor

Answer 4

CD81 receptors

claudin-1

Question 5

Most sensitive HCV infection

Answer 5

HCV RNA

Question 6

Entirely transmitted NonA NonB hepatitis

Answer 6

Hep E

Question 7

extrahepatic manifestations of Hep

Answer 7

serum-sickness like syndrome
GN
generalized vasculitis
essential mixed cryoglobulinemia

Question 8

Hep B; arthritis, cutaneous vasculitis (palpable purpura) +/- GN with circulating cryoprecipitable immune complexes of more than one immunoglobulin class

Answer 8

essential mixed cryoglobulinemia

Question 9

acidophilic degeneration of hepatocytes

Answer 9

councilman/apoptptic bodies

Question 10

Liver damage in hepatitis

Answer 10

• hepatitis cell degeneration and necrosis
• cell dropout
• ballooning of cells
• acidophilic degeneration of hepatocytes

Question 11

Large hepatocytes with ground glass appearance

Answer 11

chronic hepatitis

Question 12

paucity of inflammation
increase in activation of sinusoidal lining cells
lymphoid aggregate

Answer 12

Hepa C

Question 13

Hepatitis

microvesicular steatosis

Answer 13

Hepa D

Question 14

common histologic feature is marked cholestasis

Answer 14

Hep E

Question 15

Component of the “bridge”

Answer 15

1. condensed reticulum
2. inflammatory debris
3. degenerating liver cells that span adjacent portal areas

Question 16

fulminant hepatitis

“acute yellow atrophy”

Answer 16

massive hepatic necrosis

Question 17

subacute or confluent necrosis

interface hepatitis

Answer 17

bridging hepatic necrosis

Question 18

AE of interferon therapy for Hepa B that is not reversible upon dose lowering

Answer 18

Autoimmune hepatitis

Question 19

High risk individuals that should receive screening for hep B

Answer 19

CHIMPA h-3 i-3 m-2

Countries endemic
Household contacts
HCV/HIV patients
HD patients
Inmates
Injection drugs
Immunosuppressed
MSM
Multiple sex contacts
Pregnant
ALT or AsT elevated

Question 20

Jaundice in sclera

Answer 20

> 43 umol or 2.5 mg/dl

Question 21

First approved therapy for hepa B

Answer 21

Interferon

Question 22

MOA lamivudine

Answer 22

Inhibits reverse transcriptase activity of HIV and HBV

Question 23

Monotherapy of ____ can induce YMDD variants in patients with HIV infection

Answer 23

Lamivudine

Question 24

First line therapy of choice in HBeAg reactive chronic hepatitis B

Answer 24

PEG IFN monotheraoy

Question 25

antiviral therapy is recommended hepatitis

Answer 25

HBeAg-negative chronic hepatitis B ALT >2 x the upper limit of normal HBV DNA >2 x 103 IU/ml