Hepatitis Antigens Flashcards Preview

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Flashcards in Hepatitis Antigens Deck (14):
1

Anti-HAV IgG

IgG antibody indicates prior HAV infection and or prior vaccination

Protects against reinfection

2

HBsAg

Antigen found on surface of HBV

Indicates current symptomatic hepatitis B infection

Envelope glycoprotein that forms spheres and tubules
May be secreted in large amounts

3

Anti-HBs

Antibody to HBsAg

indicates immunity to hepatitis B

Vaccination

4

HBcAg

Antigen associated wit core of HBV

Within hepatocyte and assembles virions
Not detected in serum

5

Anti-HBc

Antibody to HBcAg
IgM= acute/recent infection (most specfic)
detected in window period between lag of HBsAg and and Anti-HBs

IgG=prior exposure or chronic infection
Positive during window period

Not in vaccinated

6

HBeAg

Second antigenic determinant in the HBV core

HBeAg indicates active viral replication
High transmissibility or high infectivity

Core within hepatocytes and assembles virion
Precore directs secretion into blood

7

Anti-HBe

Antibody to HBeAG

indicates low transmissibility

8

Acute HBV serum markers

HBsAg
HBeAG
Anti-HBc IgM

9

Window HBV infection

Anti-HBe

Anti-HBc IgM

10

Chronic HBV with high infectivity serum markers

HBsAg

HBeAg

Anti-HBc IgG

11

Chronic HBV with low infectivity

HBsAg

Anti-HBe

Anti-HBc IgG

12

Recovery HBV serum markers

Anti-HBs

Anti-HBe

Anti-HBc IgG

13

Immunized HBV serum markers

Anti-HBs

14

Anti-HAV (IgM)

IgM antibody to HAV

Best test to detect active hepatitis A