Hepatitis Antigens Flashcards
Anti-HAV IgG
IgG antibody indicates prior HAV infection and or prior vaccination
Protects against reinfection
HBsAg
Antigen found on surface of HBV
Indicates current symptomatic hepatitis B infection
Envelope glycoprotein that forms spheres and tubules
May be secreted in large amounts
Anti-HBs
Antibody to HBsAg
indicates immunity to hepatitis B
Vaccination
HBcAg
Antigen associated wit core of HBV
Within hepatocyte and assembles virions
Not detected in serum
Anti-HBc
Antibody to HBcAg
IgM= acute/recent infection (most specfic)
detected in window period between lag of HBsAg and and Anti-HBs
IgG=prior exposure or chronic infection
Positive during window period
Not in vaccinated
HBeAg
Second antigenic determinant in the HBV core
HBeAg indicates active viral replication
High transmissibility or high infectivity
Core within hepatocytes and assembles virion
Precore directs secretion into blood
Anti-HBe
Antibody to HBeAG
indicates low transmissibility
Acute HBV serum markers
HBsAg
HBeAG
Anti-HBc IgM
Window HBV infection
Anti-HBe
Anti-HBc IgM
Chronic HBV with high infectivity serum markers
HBsAg
HBeAg
Anti-HBc IgG
Chronic HBV with low infectivity
HBsAg
Anti-HBe
Anti-HBc IgG
Recovery HBV serum markers
Anti-HBs
Anti-HBe
Anti-HBc IgG
Immunized HBV serum markers
Anti-HBs
Anti-HAV (IgM)
IgM antibody to HAV
Best test to detect active hepatitis A
