Hepatocellular Carcinoma Flashcards
what is the most common cause of hepatocellular carcinoma worldwide?
chronic hepatitis B
what is the most common cause of hepatocellular carcinoma in europe?
chronic hepatitis C
what is the main risk factor for developing hepatocellular carcinoma (HCC)?
liver cirrhosis secondary to:
* hepatitis B/C
* alcohol
* haemaochromatosis
* primary biliary cirrhosis
what are the risk factors for hepatocellular carcinoma (HCC)?
- hepatitis B/C
- alcohol
- haemochromatosis
- primary biliary cirrhosis
- alpha-1 antitrypsin deficiency
- hereditary tyrosinosis
- glycogen storage disease
- aflatoxin
- drugs
- porphyria cutanea tarda
- male sex
- diabetes mellitus
what drugs increase someones risk for developing hepatocellular carcinoma (HCC)?
- oral contraceptive pill
- anabolic steroids
what are the features of hepatocellular carcinoma (HCC)?
- tends to present late
- liver cirrhosis or failure = jaundice, ascites, RUQ pain, hepatomegaly, pruritus, splenomegaly
- raised AFP
who should be screened for hepatocellular carcinoma (HCC)?
- liver cirrhosis secondary to heptatitis B/C or haemochromatosis
- men with liver cirrhosis secondary to alcohol
how is hepatocellular carcinoma (HCC) screened for?
ultrasound +/- alpha-fetoprotein
what are the management options in hepatocellular carcinoma (HCC)?
- early disease = surgical resection
- liver transplantation
- radiofrequency ablation
- transarterial chemoembolisation
- sorafenib
what is sorafenib?
multikinase inhibitor
