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PANCE > high yield 4 > Flashcards

high yield 4 Flashcards

1
Q

paget disease bone

labs, signs, tx

A
  1. enlarged skull + deaf
  2. bone pain
  3. increase ALK PHOS
    tx: bisphosphonates
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2
Q

myxedema coma

A

extreme hypothyroidism

  1. bradycardia
  2. hypothermia
  3. hypotension
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3
Q

Addison’s disease Lab

A

hyponatremia, hyperkalemia

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4
Q

Addison’s dx

A

HIGH dose ACTH ( Cosyntropin) stim test

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5
Q

Addison tx

A

corticosteroid replacement
1st- hydrocortisone
mineralcorticoid repalcement- fludrocortisone

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6
Q

addisonian crisis

A

addisons disease + shock

caused by stressor

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7
Q

cushing’s endogenous cause

A

pituitary adenoma leading to ACTH overproduction

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8
Q

Cushing’s dx

A

1st -24 hour urinary free cortisol

high dose dexamethasone suppression test

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9
Q

Cushings labs

A

hyperglycemia, hyokalemia, dyslipidemia, met alkalosis

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10
Q

Conn’s syndrome

A

adrenal aldosteronoma

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11
Q

primary hyperaldosteronism

A

renin-independent
bilateral adrenal hyperplasia
or conn’s ( adrenal aldosternoma)

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12
Q

primary hyperaldosteronism

sxs

A

TRIAD:

HTN, low K, met alkalosis (similar to cushings)

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13
Q

tx of primary hyperaldosteronism

A

bilat hyperplasia: spironolactone + ACEi

conn: spironolactone + surgical excision

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14
Q

primary hyperthyroidism

dx

A

aldosterone to renin ration

ARR >20:1

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15
Q

Pheochromocytoma

s/s

A

P: palpitations
H: Headache (MC)
E: excessive sweating

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16
Q

Pheochromocytoma

dx

A

24hr urine fractionated catecholamines

–> increaased metanephines and vanillylmandelic acid

17
Q

Pheochromocytoma

tx

A
  1. nonselective alpha blockade : PHEoxybenzamine or PHEntolamine 1-2weeks
  2. FOLLOWED by Beta blockade
    ( can lead to HTN crisis if BB first!!)
  3. SURGERY- -2 weeks after meds
18
Q

med causes of hypothyroidism

A
  1. lithium
  2. amiodorone (also causes hyperthyroidism)
  3. alpha interferon

PANCE (5 decks)

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