HIGH YIELD-NSAIDS

Question 1

how do NSAIDs act?

Answer 1

inhibiting the prostaglandin enzymes (COXs)

Question 2

what are the types of NSAIDs?

example?

Answer 2

most are competitive, noncompetitive, or mixed reversible inhibitors of COX

aspirin is a noncompetitive, irreversible inhibitor

Question 3

NSAIDs treat?

Answer 3

inflammation
pain
fever

Question 4

PGE2 and PGI2 mediate?

which one crosses the BBB?

Answer 4

inflammation and pain

PGE2

Question 5

what are the COX enzymes?

Answer 5

COX-1

COX-2

Question 6

NSAID PK elimination via?

Answer 6

short and long acting

Question 7

adverse effects what systems?

Answer 7

GI
CV
Renal
others
-increased bleeding
-hypersensitivity
-hepatic

Question 8

GI BBW?

Answer 8

serious-bleeding, ulcers, and perforation

inhibition of COX-1, PGI2 and PGE2 inhibit acid secretion

Question 9

CV BBW?

Answer 9

COX-1 affects TXA2 causing vasoconstriction and platelet aggregation

MI, heart failure, stroke, HTN

COX-2 agents have a higher risk of CV toxicity

Question 10

Renal AE?

affect of NSAIDs and ACE/ARB

Answer 10

sodium and water retention, increased BP

increases potassium levels

acute kidney injury (AKI)
-kidney loses perfusion

*NSAIDS constrict afferent arteriole, and ACE/ARB dilate the efferent arteriole

Question 11

what are the warnings of NSAIDs?

Answer 11

NSAIDs can cross the placenta and may cause premature closure of the ductus arteriosus

Question 12

what are the drug-drug interactions?

Answer 12

ACE inhibitors, ARBs
corticosteroids
anticoagulants
lithium w/ NSAIDs raises it levels up b/c it looks like Na and we know Na gets reabsorbed

Question 13

what are the NSAIDs?

Answer 13

aspirin
ibuprofen
naproxen
indomethacin
ketorolac
diclofenac

Question 14

what are the COX-2 selective inhibitors?

Answer 14

celecoxib
meloxicam
nabumetone
etodolac
acetaminophen