MOA OBESITY

Question 1

sympathomimetic amine that stimulates the hypothalamus to release norepinephrine and dopamine, suppresses appetite

Answer 1

phentermine

Question 2

sympathomimetic amine that also stimulates the hypothalamus to release NE

Answer 2

diethylproprion

Question 3

combination drug:

sympathomimetic amine that stimulates the hypothalamus to release norepinephrine and dopamine, suppress appetite

suppresses appetite and enhances satiety by modulating GABA receptors

Answer 3

phentermine-topiramate

Question 4

selective agonism at the 5HT2C receptors that promotes satiety and indicated for chronic wt management

Answer 4

lorcaserin

Question 5

this is a GI lipase inhibitor that blocks absorption of dietary fats and triglycerides from the diet, acts locally and not absorbed systemically and so if patient doesn’t have a lot of fat in diet this isn’t useful

Answer 5

orlistat

Question 6

this is a glucose like peptide 1 (GLP-1) agonist that decreases inappropriate glucagon secretion

Answer 6

liraglutide

Question 7

this is DA/NE reuptake inhibitor + opioid antagonist used for depression and smoking cessation

Answer 7

bupropion

Question 8

this is DA/NE reuptake inhibitor + opioid antagonist used for opioid and alcohol dependence

Answer 8

naltrexone