Higher Cortical Function Flashcards

1
Q

Outline the structure of the cerebral cortex

A

arranged as 6 laters containing cell bodies + dendrites (grey matter)

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2
Q

What are most of the outputs of the cortex from?

A

Axons of pyramidal neurones

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3
Q

Three types of output fibres

A
  • Projection fibres: from cortex to brainstem
  • Commissural fibres: between hemispheres
  • Association fibres: connecting nearby regions of cortex in same hemisphere
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4
Q

Where are most of the inputs to the cortex from

A

Thalamus
Other cortical areas

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5
Q

Function of frontal lobe

A
  • voluntary motor control
  • expression of speech (left)
  • behavioural regulation
  • cognition
  • eye movements
  • continence
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6
Q

Function of parietal lobe

A
  • somatosensory perception
  • comprehension of speech (left)
  • body image (right)
  • spatial awareness
  • calculation + writing
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7
Q

Function of temporal lobe

A
  • hearing
  • smell
  • taste
  • memory
  • emotion
  • long term memory
  • comprehension of speech (left)
  • emotion at limbic system
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8
Q

What hemisphere is dominant in most people?

A

Left

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9
Q

What is the left hemisphere dominant for?

A

Language
Mathematical/logical function

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10
Q

What is the right hemisphere dominant for?

A

Body image
Visuospatial awareness
Emotion
Musical ability

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11
Q

Where are the language pathways dominants?

A

Left hemisphere

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12
Q

What is involved in language pathways + their function?

A
  • Broca’s area: production of speech
  • Wernicke’s area: interpretation of language
  • arcuate fasciculus: connects the two
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13
Q

Pathway for repeating a heard word

A

left hemisphere
- auditory cortex in temporal lobe
- signal sent to wernicke’s area
- signal to Broca’s area via arcuate fascicilus
- signal sent to primary motor cortex to elicit speech

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14
Q

Pathway for speaking a written word

A
  • left hemisphere
  • visual cortex in occipital lobe
  • signal sent to wernicke’s area
  • signal to Broca’s area via arcuate fascicilus
  • signal sent to primary motor cortex to elicit speech
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15
Q

Location of Broca’s area

A

Inferior lateral frontal lobe

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16
Q

Location of Wernicke’s area

A

Superior temporal lobe

17
Q

What can damage to Broca’s area cause?

A

Expressive aphasia
Staccato speech
Patient will still understand what is being said to them but can’t speak properly

18
Q

What can damage to Wenicke’s area cause?

A

Receptive aphasia
Fluent, nonsensical speech
But patient doesn’t appear to understand what is being said to them

19
Q

What does damage to the arcuate fasciculus cause?

A

Inability to repeat heard words

20
Q

What are the types of memory?
What do they store and where?

A
  • declarative/explicit: factual information in cerebral cortex
  • non-declarative/implicit: motor skills + emotion in subcortical structures e.g. basal ganglia + cerebellum
  • short term memory: in cortical circuits
  • long term memory: in cerebral cortex, cerebellum
21
Q

What does declarative/explicit memory store + where?

A

Factual information
In cerebral cortex

22
Q

What does non-declarative/implicit memory store + where?

A
  • Motor skills + emotion
  • stored in subcortical structures e.g basal ganglia + cerebellum
23
Q

Where is short vs long term memory stored?

A
  • short: in cortical circuits
  • long: in cerebral cortex, cerebellum
24
Q

What is consolidation?

A

Process of converting short term memories into long term memories

25
What factors influence consolidation?
- emotional context - rehearsal - association
26
Location of hippocampus
Deep in temporal lobe
27
Function of hippocampus
Facilitates consolidation of memories in cortex via its output pathways
28
Outline the main output pathway of the hippocampus
Fornix > mammillary bodies > thalamus > cortex
29
What is the key molecular mechanism of memory consolidation?
Long term potentiation
30
Role of long term potentiation in memory consolidation
- Causes changes in glutamate receptors in synapses - Leads to synaptic strengthening
31
What is alien hand syndrome?
When one hand has a ‘mind of its own own’ and is not controlled properly by the brain
32
What causes alien hand syndrome?
Damage in corpus callosum
33
What is aphasia?
Acquired disorder of language resulting from brain damage to dominant hemisphere
34
What is dysarthria?
Form of motor speech disorder which involves the abnormal articulation of sounds affecting speed, strength, timing, range + accuracy of movements
35
What can damage to corpus callosum cause?
Alien hand syndrome Effects on language processing
36
What can cause global aphasia?
Middle cerebral artery stroke
37
What do the inferior and superior division of MCA supply?
**superior** - Broca’s area **inferior** - Wernicke’s area