Histamine Antagonists and Proton Pump Inhibitors Flashcards Preview

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Flashcards in Histamine Antagonists and Proton Pump Inhibitors Deck (23):
1

Cimetidine

Histamine H2 receptor antagonist

2

Histamine H2 receptor antagonist MOA

Blocks histamine H2 receptors and decreases gastric acid secretion

3

Cimetidine Side Effects

Gynecomastia with long-term use and in some incidences impotence

4

Ranitidine

Histamine H2 receptor antagonist

5

Ranitidine Side Effects

Rare but include agitation, anemia, confusion and depression

6

Omeprazole

PPI (proton pump inhibitor)

7

PPI (Proton pump inhibitor) MOA

Inhibits H+/K+ pump (proton pump) in the gastric parietal cells

8

PPI [Omeprazole, Rabeprazole] contraindications

Can increase concentrations of diazepam, warfarin, and phenytoin by decreasing their clearance by the liver; PPIs can reduce absorption of ketoconazole and increase absorption of digoxin

9

Rabeprazole

PPI (proton pump inhibitor)

10

Omeprazole Side Effects

Diarrhea, nausea, skin rash, dizziness

11

Rabeprazole Side Effects

Headache

12

Sucralfate

Mucosal Protective Agent

13

Mucosal Protective Agent (Sucralfate) MOA

Binds selectively to necrotic tissue to form a barrier against gastric acid

14

Sucralfate Contraindications

Can decrease absorption of cimetidine, ciprofloxacin, digoxin, ofloxacin, ranitidine if given simultaneously with Sucralfate
Grapefruit promotes absorption of Al in sucralfate--problem in patients with renal insufficiency/failure

15

Sucralfate Side Effects

Minor: constipation, flatulance, dry mouth, diarrhea, nausea

16

Tums, Maalox, Mylanta

Antacids

17

Ranitidine

Histamine Antagonist

18

Famotidine

Histamine Antagonist

19

Cimetidine

Histamine Antagonist

20

Nizatidine

Histamine Antagonist

21

Lansoprazole

PPI

22

Pantoprazole

PPI

23

Esomeprazole

PPI