HISTORY

Question 1

These people first used Inhalation or Insuffation of dried powders from small pox lesion, which will cause minimal effects when exposed early

Answer 1

1500 CHINESE

Question 2

Smallpox vaccine was first discovered by exposing individuals to cowpox lesion which creates “artificial immunity” or “cross immunity”

Answer 2

1798 EDWARD JENNER

Question 3

Phagocytosis or engulfment of cells was discovered

Answer 3

1862 Haeckel

Question 4

He is the “Father of Immunology”, which discovered the Attenuation of bacteria Pasteurella multocida by the use of Chicken cholera. He also attenuated the vaccine for Rabies.

Answer 4

1880-1881 LOUIS PASTEUR

Question 5

PROCESS OF ATTENUATION

Answer 5

HEAT, AGING, CHEMICAL MEANS

Question 6

1883 Elie Metchinikoff

Answer 6

Cellular theory of immunity through Phagocytosis
He discovered the phagocytosis

Question 7

Humoral Theory of Immunity

Answer 7

Emil Von Behring and Kitasata

Question 8

Type IV Delayed Type Hypersensitivity

Answer 8

1891 Robert Koch

Question 9

Complement mediated cytolysis

Answer 9

1894-1895 Pfeiffer and Buchner

Question 10

Discovery of Agglutination reaction

Answer 10

1896 Gruber and Durham

Question 11

1896 Ferdinand Widal

Answer 11

Widal Test, Discovery of agglutination reaction for typhoid fever diagnosis

Question 12

Antibody formation and Side Chain theory

Answer 12

1900 Paul Ehrlich

Question 13

Discovery of ABO Blood Group

Answer 13

1900 Karl Landsteiner

Question 14

Discovery of the most severe form of hypersensitivity (Type I Immediate hypersensitivity)

Answer 14

1902 Portier and Charles Richet

Question 15

Discovery of Type III Hypersensitivity

Answer 15

1903 Arthus

Question 16

Process by which a particular antigen becomes more susceptible to phagocytosis

Answer 16

Opsonization

Question 17

Discovery of Opsonins

Answer 17

1903 Almoth Wright, Stephen Douglas, Joseph Denys

Question 18

1903 George Snell

Answer 18

Genetics of the murine MHC Class 1-3

Question 19

Describes the relationship between immunity and hypersensitivity

Answer 19

1906 Von Pirquet and Schick

Question 20

1906 Jean Dausset

Answer 20

Early pioneer in the study of MHC and HLA

Question 21

Developed the Hemolytic Plaque Assay

Answer 21

1911 Niel Jerne

Question 22

Father of Transplantation, and Acquired Immunologic Response

Answer 22

1915-1987 Peter Medawar

Question 23

Study of the Complement System

Answer 23

1920 Jules Bordet

Question 24

1920 Barui Bernaceraf

Answer 24

Discovery of immune response genes and regulation

Question 25

1920-1985 Rodney Porter

Answer 25

Discovery of polypeptide structure of Antibody

Question 26

Vaccine against tuberculosis

Answer 26

1921 Albert Calmette and Camille Guerin

Question 27

1921 Rosalyn Yalow

Answer 27

Developed Radioimmunoassay of peptide hormones

Question 28

Discovery of Penicillin and description of action of lysozymes

Answer 28

1922 Alexander Flemming

Question 29

1924 James Gowan

Answer 29

Discovered that Adaptive Immunity is mediated by lymphocytes

Question 30

1927 Cesar Milstein and Georges Kohler

Answer 30

Developed the technique of monoclonal Antibody formation

Question 31

1929 Gerald Edelman

Answer 31

Discovery of immunoglobulin structure and complete sequence of Antibody molecule

Question 32

Discovery of vaccine against Yellow Fever

Answer 32

1930 Max Theiler

Question 33

Lattice hypothesis, Antigen-antibody hypothesis

Answer 33

1938 Marrack

Question 34

Discovers the Somatic Recombination

Answer 34

1939 Susumu Tonegawa

Question 35

Development of Polio Vaccine

Answer 35

1949 Salk and Sabin

Question 36

1957 Burnet

Answer 36

Clonal Selection Theory, Memory Cell, Plasma Cells, Apoptosis

Question 37

Substance that interfered with viral replication

Answer 37

Interferons

Question 38

Discovery of Interferons

Answer 38

1957 Alic Isaacs and Jean Lindemann

Question 39

1980 Luc Montaigner

Answer 39

Discovery of Lymphadenopathy Associated Virus (LAV)

Question 40

Renamed the retrovirus as Human Immunodeficiency Virus

Answer 40

1980 Robert Gallo

Question 41

1986 Mosmann

Answer 41

Th1 and Th2 model of T Helper function

Question 42

Factors affecting Innate Immunity

Answer 42

Age Nutrition Fatigue Stress Genetic determinants