HIV. 2

Question 1

Name the three ART drugs that need Renal Adjustments state their dose .

Answer 1

Zidovudine CrCl > 15 /Hemodialysis 300mg od

lamivudine
CrCl 30 -49 150 mg od
15 -29 100mg
5-14 50 mg od

Tenofovir
CrCl 30-49 : 300mg q 2day
10- 29 300mg 2 / week

Question 2

What is the available liquid dosage for ZIDOVUDINE , LAMIVUDINE and Nevirapine

Answer 2

ZIDOVUDINE 10mg / ml * 240 ml
LAMIVUDINE 10mg/ml * 240 ml
NEVIRAPINE 50 mg / 5 ml * 100 ml

Question 3

True or false
SIMVASTATIN WILL CAUSE MAJOR INTERACTIONS WITH
RITONAVIR , EFAVIRENZ , NEVIRAPINE AND OTHER PI

Answer 3

True : these drugs induces CYP 450 thus will increase Sivas .