Flashcards in HIV Deck (39)
1. identify the main routes of HIV transmission
2. know the key elements of HIV structure and replication
3. infer the mechanism of HIV disease from its mode of replication
a zoonotic disease
few virons breach the
epithelium and establish infection
brief window to
attempt prevention with drugs or vaccines
tissue macrophages, dendritic cells
infected cells produce
virons and also migrate to lymph nodes where further infections occur
how do virons spread?
they spread from regional lymph nodes and gut lymphoid tissue (GALT) to other sites
what are the routes of transmission?
1. sexual contact
lymphoid cells that are embedded in the vaginal and rectal epithelium, then spreads to lymph nodes and blood
HIV is an RNA virus and also classified as
HIV is also considered as
Lentivirus, which means slow to cause dz
2. + strand
3. two copies in each viron (diploid)
Describe the route of HIV infection
HIV infects lymphoid cells that are embedded in the vaginal and rectal epithelium, then spreads to the lymph nodes and blood
HIV is an
HIV is also called
lentivirus, which means slow to cause dz
Is HIV monoploid?
no it's diploid
what are the 2 components of HIV envelope?
TM = transmembrane, gp41
SU = surface, gp120
SU, gp120 binds to
CD4 and chemokine receptor (CCRs), which causes conformational change in TM
CCR usage shifts between what?
CCR5 (macrophage) and CXCR4 (T cells)
presence of what determines susceptibility to HIV infection?
presence of CCR (Chemokine receptors)
after needle stick
PEP = post exposure prophylaxis
almost eliminated as risk factor for HIV are
mother to fetus, and infection from blood products
routes of HIV transmission depend on
2/3 of the HIV transmission happens through
bisexual and Gay men
HIV introduced to humans from
what are the 2 routes of transmission?
sexual contact, blood
what does HIV infect?
lymphoid cells that are embedded in the vaginal and rectal epithelium, then spreads to the lymph nodes and blood
what does lentivirus mean?
slow to cause dz (not slow to replicate)
ssRNA and + strand