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Flashcards in HIV Deck (39)
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1

learning objectives?

1. identify the main routes of HIV transmission
2. know the key elements of HIV structure and replication
3. infer the mechanism of HIV disease from its mode of replication

2

HIV is

a zoonotic disease

3

few virons breach the

epithelium and establish infection

4

brief window to

attempt prevention with drugs or vaccines

5

virones infect

tissue macrophages, dendritic cells

6

infected cells produce

virons and also migrate to lymph nodes where further infections occur

7

how do virons spread?

they spread from regional lymph nodes and gut lymphoid tissue (GALT) to other sites

8

what are the routes of transmission?

1. sexual contact
2. blood

9

HIV infects

lymphoid cells that are embedded in the vaginal and rectal epithelium, then spreads to lymph nodes and blood

10

HIV is an RNA virus and also classified as

Retroviridae

11

HIV is also considered as

Lentivirus, which means slow to cause dz

12

HIV is

1. ssRNA
2. + strand
3. two copies in each viron (diploid)

13

Describe the route of HIV infection

HIV infects lymphoid cells that are embedded in the vaginal and rectal epithelium, then spreads to the lymph nodes and blood

14

HIV is an

RNA virus

15

HIV is also called

lentivirus, which means slow to cause dz

16

Is HIV monoploid?

no it's diploid

17

what are the 2 components of HIV envelope?

TM = transmembrane, gp41
SU = surface, gp120

18

SU, gp120 binds to

CD4 and chemokine receptor (CCRs), which causes conformational change in TM

19

CCR usage shifts between what?

CCR5 (macrophage) and CXCR4 (T cells)

20

presence of what determines susceptibility to HIV infection?

presence of CCR (Chemokine receptors)

21

after needle stick

PEP = post exposure prophylaxis

22

almost eliminated as risk factor for HIV are

mother to fetus, and infection from blood products

23

routes of HIV transmission depend on

cultural factor

24

2/3 of the HIV transmission happens through

bisexual and Gay men

25

HIV introduced to humans from

chimpanzee

26

what are the 2 routes of transmission?

sexual contact, blood

27

what does HIV infect?

lymphoid cells that are embedded in the vaginal and rectal epithelium, then spreads to the lymph nodes and blood

28

what does lentivirus mean?

slow to cause dz (not slow to replicate)

29

HIV is

ssRNA and + strand

30

HIV has

two copies in each virion (diploid)