HIV Flashcards
1
Q
List seven HIV drug classes
A
- Nucleoside/Nucleotide reverse Transcriptase Inhibitors (NRTI)
- Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTI)
- Protease Inhibitors/PK Boosters
- Integrase Strand Transfer Inhibitors (INSTI)
- CCR5 Antagonists
- Fusion Inhibitors
- CD4-Directed Post-Attachment HIV-1 Inhibitor
2
Q
List 8 NRTI used in HIV
A
- Ziagen (abacavir)
- Epivir (Lamivudine)
- Emtriva (emtricitabine)
- Viread (tenofovir disoproxil fumarate)
- TAF (tenofovir alafenamide)
- Retrovir (Zidovudine)
- Zerit (Stavudine)
- Videx (Didanosine)
3
Q
List four NNRTI used in HIV
A
- Sustiva (Efavirenz)
- Edurant (Rilpivirine)
- Viramune, Viramune XR (Nevirapine)
- Intelence (Etravirine)
4
Q
List eight protease inhibitors used in HIV
A
- Prezista (Darunavir)
- Reyataz (Atazanavir)
- Lexiva (Fosamprenavir)
- Crixivan (Indinavir)
- Kaletra (Lopinafivr + ritonavir)
- Viracept (Nelfinavir)
- Invirase (Saquinavir)
- Aptivus (Tipranavir)
5
Q
List two pharmacokinetic boosters used in HIV
A
- Norvir (Ritonavir)
2. Cobicistat (Tybost)
6
Q
List four INSTIs used in HIV
A
- Elvitegravir
- Bictegravir (contained in Biktarvy)
- Tivicay (Dolutegravir)
- Isentress (Raltegravir)
7
Q
List 1 CCR5 antagonist used in HIV
A
- Selzentry (Maraviroc)
8
Q
List 1 fusion inhibitor used in HIV
A
- Fuzeon (Enfuvirtide)
9
Q
List 1 CD-4 directed post-attachment HIV-1 inhibitor
A
- Trogarzo (Ibalizumab-uiyk)
10
Q
List 1 PI-based single tablet regimen
A
- Symtuza (Darunavir + Cobicistat + emtricitabine + tenofovir alafenamide)
11
Q
List five NNRTI-based single tablet regimens
A
- Atripla (Efavirenz + emtricitabine + tenofovir disoproxil fumarate)
- Symfi (Efavirenz 600 mg+ lamivudine + TDF)
- Symfi lo (Efavirenz 400 mg + lamivudine + TDF)
- Complera (Rilpivirine + emtricitabine + TDF)
- Odefsey (Rilpivirine + emtricitabine + tenofovir alafenamide)
12
Q
List five INSTI-based single tablet regimens
A
- Stribild (elvitegravir + cobicistat + emtricitabine + TDF)
- Genvoya (elvitegravir + cobicistat + emtricitabine + tenofovir alafenamide)
- Biktary (Bictegravir + emtricitabine + tenofovir alafenamide)
- Triumeq (Dolutegravir + abacavir + lamivudine)
- Juluca (Dolutegravir + rilpivirine)
13
Q
What is contained in Epzicom?
A
abacavir + lamivudine
14
Q
what is contained in Truvada?
A
emtricitabine + TDF
15
Q
With or without food: Atazanavir and Evotaz
A
With (PI)
16
Q
With or without food: darunavir and prezcobix
A
with (PI)
17
Q
With or without food: Atripla
A
without
18
Q
With or without food: Efavirenz
A
without
19
Q
With or without food: Indinavir (boosted)
A
with (PI)
20
Q
With or without food: Kaletra oral solution
A
with (contains ritonavir)
21
Q
With or without food: Symfi
A
without
22
Q
With or without food: nelfinavir
A
with (PI)
23
Q
With or without food: ritonavir
A
with (PI)
24
Q
With or without food: symfi lo
A
without
25
With or without food: saquinavir
with (PI)
26
With or without food: tipranavir
with (PI)
27
With or without food: Genvoya
with (package insert)
28
With or without food: Complera
with (because of rilpivirine)
29
With or without food: Juluca
with (because of rilpivirine)
30
With or without food: Odefsey
with (because of rilpivirine)
31
With or without food: Stribild
with
32
With or without food: Symtuza
with (because of darunavir)
33
With or without food: Indinavir (unboosted)
without
34
With or without food: didanosine
without
35
List 22 HIV medications that must be dispensed in original container
1. Atripla
2. Biktarvy
3. Cimduo
4. Complera
5. Descovy
6. Genvoya
7. Juluca
8. Odefsey
9. Stribild
10. Symfi and Symfi Lo
11. Symtuza
12. Triumeq
13. Truvada
14. Darunavir
15. Dolutegravir
16. Etravirine
17. Indinavir
18. Nelfinavir
19. Raltegravir
20. Ritonavir
21. Rilpivirine
22. Tenofovir disoproxil fumarate
36
NRTI class effect?
Lactic acidosis
37
NNRTI class effect?
rash
38
PI class effect?
metabolic abnormalities (hyperlipidemia, hyperglycemia, lipohypertrophy) and N/V/D
39
Common ADR of abacavir?
Hypersensitivity and possible increase risk of MI
40
Common ADR of didanosine?
Pancreatitis and peripheral neuropathy
41
Common ADR of emtricitabine
Headache
42
Common ADR of lamivudine?
Headache
43
Common ADR of stavudine?
Pancreatitis and peripheral neuropathy
44
Common ADR of Tenofovir (TDF and TAF)
Renal toxicity (fanconi syndrome) and decreased bone mineral density
45
Common ADR of Zidovudine?
Macrocytic anemia and myopathy
46
Common ADR of Efavirenz?
CNS effects (impaired concentration, abnormal dreams, confusion)
47
Common ADR of Nevirapine?
Hepatotoxicity and hypersensitivity
48
Common ADR of Etravirine?
SJS/TEN
49
Common ADR of Rilpivirine?
Depression and Insomnia
50
Common ADR of darunavir?
Headache
51
Common ADR of atazanavir?
Nephrolithiasis and indirect hyperbilirubinemia
52
Common ADR of fosamprenavir?
rash
53
Common ADR of indinavir?
Nephrolithiasis and urolithiasis
54
Common ADR of lopinavir/ritonavir?
hypertriglyceridemia
55
Common ADR of nelfinavir?
Diarrhea
56
Common ADR of ritonavir?
N/V/D
57
Common ADR of saquinavir?
Nausea
58
Common ADR of Tipranavir?
Intracranial hemorrhage
59
Common ADR of Raltegravir?
Increased CPK, myopathy and rhabdo
60
Common ADR of Elvitegravir?
Headache and insomnia
61
Common ADR of dolutegravir?
Increased SCr without effecting GFR
