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Flashcards in Holmes 3 Deck (14):
1

After the peak of depolarization, the Nav channel are INACTIVATED (use of the 'stopper' instead of 'closed' gate). What does this mean?

-Stops Na flow but unlike 'closed' state, the 'inactive state is not competent to open in response to depolarization
-the 'ball' is released from the Nav channels following hyperpolarization and the membrane returns to resting potential

2

What is the purpose of the inactive Nav state?

Allows for direction propagation of action potentials down the axon to the axon terminals (called refractory period)

3

How much sodium enters the cell during an AP?

~10^-12 moles

4

Can we fire an AP during absolute refractory? relative refractory? (after depolarization)

NO

Yes for relative refractory if there is a more negative Vm requiring stronger depolarization current

5

What is saltatory conduction? Orthodromic propagation? Antidromic propagation?

Saltatory conduction: the leaping of AP in myelinated nerves between nodes of Ranvier

Orthodromic propagation: AP propagation from soma to presynaptic terminal

Antidromic propagation: Propagation in opposite direction

6

What is accomodation?

Increase in threshold for firing AP that occurs during prolonged depolarization
-result of Nav inactivation
-results in fewer AP generated during prolonged depolarization

7

T/F, APs fired from diff cells can be very diff in size, shape, and duration.

True

8

What is neuromodulation?

Molecular/ionic basis of sculpting diff patterns in action potentials

9

What are some toxins/medications associated with ion channels? Nav blockers? Nav inhibitors? Kv blockers?

block Nav: local anesthetics (lidocaine)

inhibit Nav: antiepileptic/anticonvulsant (phenytoin and carbamazepine)

block delayed Kv channels: antiarrhythmic drugs (dofetilide)

Tetrodotoxin (TTX) from fugu and saxitoxin (STX) from red tide are paralytic toxins that block Nav

10

What is propofol (diprivan)?

general anesthesia: blocks Nav channels, KILLED THE KING OF POP MJ

11

How can we treat severe opioid-resistant pain?

Cone snail poison

12

What are channelopathies? Examples?

Diseases that alter function of ion channels. Genetic or acquired

ex. arrhythmia Long QT syndrome, CYSTIC FIBROSIS, hypertension, timothy syndrome (affects voltage gated Ca channel)

13

What is characteristic of periodic paralysis?

One moment of enhanced excitability followed by inexcitability and weakness a few minutes later

14

What is myotonia?

Impairment of muscle relaxation, can be diminished with repeated contractions.

Unlike cramp, it is painless