Hormonal Manipulation of Reproductive Function Flashcards
Indications: Stimulation of Follicular Development
Earlier onset to the breeding season
More offspring produced per year
Production of offspring out-of-season
Year-round milk supply (dairy goats)
Techniques: Stimulation of Follicular Development
Photoperiod/melatonin manipulation
GnRH or GnRH agonists
Gonadotropins (FSH, eCG)
Male (Whitten) effect
Photoperiod
Increase day length = decreased melatonin = stimulates reproduction in cats and horses
Long day breeders
eCG has FSH-like biological activity when administered in ______________
Ruminants
Stimulation of follicular development
Male (Whitten) Effect
Stimulation of follicular development
Introduction of new/novel male into herd = advance onset of the breeding season
Indications: Induction of Ovulation
Stimulation of a timed ovulation for artificial insemination
Treatment of cystic follicles (cattle)
Synchronization of ovulations
Decreasing the duration of estrus
Following AI in induced ovulators
Hormones: Stimulation of Follicular Development
GnRH and GnRH agonists
FSH
eCG
Hormones: Induction of Ovulation
GnRH or GnRH agonists
LH
hCG
Coital stimulation (induced ovulators)
hCG has LH-like biological activity in _____________
All species
Induction of ovulation
Principles of GnRH Therapy
Administrationof GnRH induces a surge of LH release from anterior pituitary
The endogenous LH surge stimulates follicular maturation and induces ovulation
Principles of hCG Therapy
hCG has LH-like biological activity and has a direct effect on the ovarian follicle
Follicle maturation and ovulation
Coital Stimulation (Cats)
Ovulation can be induced by stimulation of the vagina and cervix
Stimulation triggers LH surge
Complication of vaginal cytology collection
Mating to a sterile male can induce ovulation
Coital Stimulation (Llamas)
Mating stimulates the vagina and cervix and causes release of LH from the pituitary
Camelid semen also contains an ovulation induction factor (nerve growth factor beta) that stimulates additional LH release from the anterior pituitary
Principles: Superovulation
Cows and mares usually ovulate a single follicle each cycle
Follicle development is stimulated by FHS
Development of other follicles is suppressed by inhibin and estradiol produced by the dominant follicle
Indications: Superovulation
Embryo transfer - increase embryo collection rate
Increase rate of multiple births
Enhance ovulation rate in the female as a method to treat subfertility