Hormonal Manipulation of Reproductive Function Flashcards

1
Q

Indications: Stimulation of Follicular Development

A

Earlier onset to the breeding season
More offspring produced per year
Production of offspring out-of-season
Year-round milk supply (dairy goats)

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2
Q

Techniques: Stimulation of Follicular Development

A

Photoperiod/melatonin manipulation
GnRH or GnRH agonists
Gonadotropins (FSH, eCG)
Male (Whitten) effect

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3
Q

Photoperiod

A

Increase day length = decreased melatonin = stimulates reproduction in cats and horses
Long day breeders

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4
Q

eCG has FSH-like biological activity when administered in ______________

A

Ruminants
Stimulation of follicular development

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5
Q

Male (Whitten) Effect

A

Stimulation of follicular development
Introduction of new/novel male into herd = advance onset of the breeding season

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6
Q

Indications: Induction of Ovulation

A

Stimulation of a timed ovulation for artificial insemination
Treatment of cystic follicles (cattle)
Synchronization of ovulations
Decreasing the duration of estrus
Following AI in induced ovulators

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7
Q

Hormones: Stimulation of Follicular Development

A

GnRH and GnRH agonists
FSH
eCG

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8
Q

Hormones: Induction of Ovulation

A

GnRH or GnRH agonists
LH
hCG
Coital stimulation (induced ovulators)

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9
Q

hCG has LH-like biological activity in _____________

A

All species
Induction of ovulation

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10
Q

Principles of GnRH Therapy

A

Administrationof GnRH induces a surge of LH release from anterior pituitary
The endogenous LH surge stimulates follicular maturation and induces ovulation

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11
Q

Principles of hCG Therapy

A

hCG has LH-like biological activity and has a direct effect on the ovarian follicle
Follicle maturation and ovulation

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12
Q

Coital Stimulation (Cats)

A

Ovulation can be induced by stimulation of the vagina and cervix
Stimulation triggers LH surge
Complication of vaginal cytology collection
Mating to a sterile male can induce ovulation

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13
Q

Coital Stimulation (Llamas)

A

Mating stimulates the vagina and cervix and causes release of LH from the pituitary
Camelid semen also contains an ovulation induction factor (nerve growth factor beta) that stimulates additional LH release from the anterior pituitary

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14
Q

Principles: Superovulation

A

Cows and mares usually ovulate a single follicle each cycle
Follicle development is stimulated by FHS
Development of other follicles is suppressed by inhibin and estradiol produced by the dominant follicle

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15
Q

Indications: Superovulation

A

Embryo transfer - increase embryo collection rate
Increase rate of multiple births
Enhance ovulation rate in the female as a method to treat subfertility

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16
Q

Techniques: Superovulation

A

Exogenous FSH or a hormone with FSH activity (i.e. eCG) to ‘rescue’ smaller follicles in a wave

17
Q

Mechanism: Superovulation

A

Administration of FSH bypasses the normal negative feedback mechanisms leading to multiple ovulations

18
Q

Mechanism: Inhibin Immunoneutralization for Superovulation

A

Neutralization of endogenous inhibin leads to increased FSH concentration, enhanced follicular development, higher ovulation rates
Prevents normal (-)FB on FSH

19
Q

Indications: Termination of Luteal Activity

A

Mismating
Short-cycling
Synchronization of estrus and ovulation
Lysis of a persistent CL
Elective abortion
Induction of parturition

20
Q

Principles: Termination of Luteal Activity (Large Animals)

A

Luteal phase of large animals is 14 to 18d
PGF only effective when a mature CL is present
CL is not susceptible to luteolytic effects of PGF until 5 days after ovulation in most species

21
Q

Indications: Estrous Synchronization

A

Increased mating efficiency (AI or timed mating)
Shortening of the birthing season
Embryo transfer to ‘line-up’ donors and recipients

22
Q

Techniques: Estrous Synchronization

A

Progesterone administration
Prostaglandin administration
Combination of above
Ovsynch program (cattle) - GnRH and PGF

23
Q

Prostaglandin Technique

A

Estrous Synchronization
1st dose: PGF causes luteolysis
Early return to estrus, ovulate again, form CL
2nd dose: synchronizes most of the herd

24
Q

Ovsynch

A

Administraiton of GnRH = luteinization or ovulation of follicles
Administration of prostaglandins 7d later = luteolysis
Administration of GnRH 2d after = induce ovulation of next follicle

25
Q

Indications: Suppression of Ovarian Activity

A

Contraception (blocking follicular development and ovulation)
Suppression of behavioral estrus