Host Reponses to Viral Infections Flashcards Preview

DD Test 3 > Host Reponses to Viral Infections > Flashcards

Flashcards in Host Reponses to Viral Infections Deck (13):
1

CPE

x

2

Syncytia

Cell fusion

3

Apoptosis

Programmed cell death

4

Interferon Response

Infectino of cells lead to production of these proteins. Cells response to IFNs through receptors , through the jak/state pathways, which induces the antiviral state

5

Anti-Viral State

Alters transcription of >100 cellular genes
Temporary bloacked of cell prolife3ration, reduces cellular metabolism, potentiates NK cell activity, increase production of Antigen presenting molecules, may lead to apoptosis

6

Innate anti-viral response

Immediate and non specific
Natural barriers, cells and soluble factors
Primes and initiates adaptive immunity
Includes TLR and RIG-1-Like Helicases which detect viral genetic data

7

Adaptive anti-viral response

Acquired over time and specific

8

Antibodies in Primary response

Lower affinity and normally IgM

9

Antibodies in Secondary Response

Higher affinity and normally IgG

10

Efficacy of antibody immunity in the anti-viral response

It honestly isn't that great because most virus are intracellular and hide from the humoral response system as they're within cells

11

Efficacy of Cell mediated immunity in the anti-viral response

The more effective approach, mediated by t-lymphocytes, as they are able to induce apoptosis in cells infected with viruses.

12

Explain means of viral evasion/manipulation of host defenses by variuos viruses

Antigenic variation, imune tolerance, restricted expression, down regulation of host molecules, infecting immunoprivileged sites, direct infection of the immune system, inhibition of apoptosis

13

Pyknosis

Nuclear Shrinking