HPIV(Human Parainfluenza Virus

Question 1

Type

Answer 1

Family:
Paramyxovirus
Genera:
Respirovirus:
HPIV 1 & 3
Rubalavirus:
HPIV 2 & 4
Linear Negative
ssRNA helical
- Enveloped
- virus replicates i
cytoplasm
- buds from
plasma
membrane

Question 2

Transmission
& season

Answer 2

Resp droplets -
fomites, person
to person
Predisposing
factors:
1. Malnutrition
2.Overcrowding
3. Vitamin A
deficiency
4. Lack of
breastfeeding
Incubation
time: 1-7 days

Question 3

presentation

Answer 3

Sx caused by CMI
1. Croup(laryngotrach
eitis) - HPIV-1
Age: 6mos-3 years
- Inspiratory stridor
- Cough(barking:infant
s & young children)
- Hoarseness(older
children & adults)
- Inflammation in larynx
and subglottic area
- Most common cause:
viruses-HPIV1

Question 4

pathogenesis

Answer 4

1. Fusion protein(F): syncytia
   formation & viral entry,evade
   immune function;
   2.Hemagglutinin-Neuraminidase
   (HN): don’t occur independently,
   G protein
   3.. L protein: multifunctional
   polymerase(RNA dependent
   RNA polymerase)
2. M protein: matrix structural
   protein
   5 P/F(phosphoprotein)
   protein(non structural) : evade
   immune response; blocks IFNa ,
   IFNb production