Klebsiella pneumoniae

Question 1

Type

Answer 1

Family:
Enterobacteriaceae
Gram -ve
bacillus
Large
polysaccharide
capsule(mucoid
appearance)
Non motile
,facultative
anaerobe
Catalase +ve
Ferments lactose
Microaerophilic

Question 2

transmission and risk factors

Answer 2

Part of
microbial floraoral cavity & intestine
At risk for CAP:
Diabetic
Alcoholics
COPD
Nosocomial
infections(ventil
ators, IV
catheters)
Exposure to
bacteria or
person-person
via
contamination
of hand or
environment(N
OT AIR)

Question 3

features

Answer 3

5 A’s of KlebsiellA and
3C’s
- Aspiration pneumo
- Abscess: Lungs & Liver
- Alcoholics
- diAbetics
- Aerobactin & enterchelin
3C’s :
- Currant jelly
sputum
- Catalase +
- Contact(transmission)

Question 4

presentation

Answer 4

Bronchopneumonia, lung
abscesses
Necrotization of lung tissue: in
response to endotoxin →
necrotic tissue mix with blood
→ capsule comes out →
Can cause severe and
destructive pneumonia
“ Red currant jelly” sputum:
thick, foul
smelling(halitosis),
tenacious(sticky)

Question 5

pathogenesis

Answer 5

1. Thick polysaccharide
   capsule(capsular
   polysaccharide-CPS/K Antigen)
2. LPS(O Antigen)
   - Prevents ingestion by
   phagocytes, detection
   of somatic antigens by
   host’s antibodies
   - Impeded complement;
   inhibits opsonization
3. Produces enzyme
   carbapenemase:
   carbapenem resistance
4. Pili(fimbriae):
   attachment to
   epithelium; biofilm
   formation
   - Tissue tropism: Type
   1- cystitis, Type 3:
   resp. Infections,
   pyelonephritis
5. Aerobactin &
   enterochelin -
   siderophores helps in
   bacterial growth