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AU'18 Oral Path II > HPV-Related Cancers - part II > Flashcards

HPV-Related Cancers - part II Flashcards

(46 cards)

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1
Q

etiology of oral squamous cell carcinoma (OSCC)

A
  1. smoking

2. ETOH

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2
Q

etiology of oropharyngeal squamous cell carcinoma (OPSCC)

A

increased number of sexual partners, majority HPV+

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3
Q

what percent of people with oropharyngeal squamous cell carcinoma (OPSCC) has HPV 16?

A

90%

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4
Q

primary clinical features of oral squamous cell carcinoma (OSCC)

A
  1. leukoplakia
  2. erythroleukoplakia
  3. erythroplakia
  4. ulcer
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5
Q

primary clinical features of oropharyngeal squamous cell carcinoma (OPSCC)

A
  1. enlarged lymph node in neck
  2. dysphagia
  3. very subtle, asymptomatic initially
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6
Q

T/F: incidence of oral squamous cell carcinoma (OSCC) is increasing

A

false, decreasing

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7
Q

T/F: incidence oforopharyngeal squamous cell carcinoma (OPSCC) is increasing

A

true

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8
Q

is there nodal involvement with oral squamous cell carcinoma (OSCC)?

A

yes

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9
Q

is there nodal involvement with oropharyngeal squamous cell carcinoma (OPSCC)?

A

yes and may be the only sign of the disease

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10
Q

gender predilection for oral squamous cell carcinoma (OSCC)

A

3 M: 1 F

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11
Q

gender predilection for oropharyngeal squamous cell carcinoma (OPSCC)

A

5 M : 1 F

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12
Q

what percent of pts with oral squamous cell carcinoma (OSCC) were smokers?

A

80-90%

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13
Q

what percent of pts with oropharyngeal squamous cell carcinoma (OPSCC) were smokers?

A

50-65%

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14
Q

does ETOH have a synergistic effect on pts with oral squamous cell carcinoma (OSCC)?

A

yes

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15
Q

does ETOH have a synergistic effect on pts with oropharyngeal squamous cell carcinoma (OPSCC)?

A

no, not significant factor

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16
Q

what is the px of oral squamous cell carcinoma (OSCC)?

A

40% survival rate

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17
Q

what is the px of oropharyngeal squamous cell carcinoma (OPSCC)?

A

80% survival rate

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18
Q

T/F: oropharyngeal squamous cell carcinoma (OPSCC) can be HPV+ or HPV-

A

true

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19
Q

T/F: all pts who have high-risk HPV in saliva will develop oropharyngeal squamous cell carcinoma (OPSCC)

Study These Flashcards
A

false, not all

20
Q

since 1988, the incidence of HPV+ oropharyngeal cancers are increasing, while HPV-oropharyngeal cancers decreased. why?

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A
  1. increase in oral sexual behavior

2. decrease in tobacco use

21
Q

T/F: dx of HPV+ oropharyngeal squamous cell carcinoma (OPSCC) is only characterized by the presence of HPV-16 alone

22
Q

what must be present for dx of HPV+ oropharyngeal squamous cell carcinoma (OPSCC)?

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A
  1. E6, E7 within tumor cells must be expressed
  2. serum presence of E6 or E7 antibodies

…this provides unambiguous dx

23
Q

tx of early HPV+ oropharyngeal squamous cell carcinoma (OPSCC)

Study These Flashcards
A
  1. platinum-based chemoradiotherapy

2. surgery

24
Q

tx of late HPV+ oropharyngeal squamous cell carcinoma (OPSCC)

Study These Flashcards
A
  1. surgery
  2. chemotherapy
  3. radiation
25
px of HPV+ oropharyngeal squamous cell carcinoma (OPSCC)
good
26
what may have a negative effect on the px of HPV+ oropharyngeal squamous cell carcinoma (OPSCC)?
comorbidities like smoking and immunodeficiency
27
list from best to worst px for HPV-related orpharyngeal cancer
1. HPV+, non-smoker 2. HPV+, smoker 3. HPV-, non-smoker 4. HPV-, smoker
28
why is HPV testing important in oropharyngeal squamous cell carcinoma?
to identify pts that should have tx de-escalated
29
HPV+ improved the survival rate of pts with oropharyngeal squamous cell carcinoma (OPSCC) by how many years?
3 years 80% for HPV+ vs 40% for HPV-
30
why does HPV+ increase the survival rate of pts with oropharyngeal squamous cell carcinoma (OPSCC)?
1. fewer genetic alterations | 2. better response to therapy (surgery and/or radiotherapy)
31
when have vaccines for HPV been available?
since August 2006
32
what does HPV vaccines prevent in BOTH males and females?
1. genital warts | 2. epithelial dysplasia and anal cancer
33
what does HPV vaccines prevent in females?
1. epithelial dysplasia 2. cervical cancer 3. vulvar cancer 4. vaginal cancer
34
why does the HPV vaccine not provide protection against diseases?
due to ALL HPV types
35
when does the HPV vaccines NOT provide protection against HPV types?
when a person has already been exposed through sexual activity
36
what percent of the Healthy People 2020 goal for complete HPV vaccine coverage for girls and boys 13 to 15 years old is finished?
80%
37
what percent of adolescents up-to-date has the HPV series?
48.6%
38
what percent of 13-17 year olds have received the 1st dose of the HPV series?
66%
39
which demographic is facing disparities in HPV vaccinations?
with urban (higher rate) and non-urban youth
40
T/F: the HPV vaccine is a tx for genital warts or HPV-related cancer
false, is NOT
41
Cervarix (GlaxoSmithKline) targets what HPV types?
16, 18
42
Guardasil (quadrivalent) targets what HPV types?
6, 11, 16, 18
43
Guardasil 9 (nonavalent) targets what HPV types?
6, 11, 16, 18, 31, 33, 45, 52, 58
44
in October 2018, the FDA approved expanded use of Gardasil 9 to include individuals of what ages?
27-45 y.o.
45
vaccines are safe. what are the side effects of a vaccine?
typical side effects... 1. erythema 2. headache 3. myalgia
46
T/F: there is strong evidence of a causal relationship between vaccines and serious health concerns
FALSE

AU'18 Oral Path II (31 decks)

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