Flashcards in HTN Day 1 Deck (33)
Types of diuretics
3. K+ sparing (aldosterone blockers & K+ sparing)
Which ACE-I is available IV?
What is unique regarding captopril?
-Must dose 2-3x/day
-Must take on empty stomach
What is the only direct renin inhibitor?
MOA of thiazides
Inhibit Na reabsorption in DCT
MOA of loop diuretics
Inhibit active transport of Na, Cl, K in ascending Loop of Henle (causing excretion)
MOA of aldosterone blockers
-Prevent Na reabsorption and K excretion
MOA of K+ sparing diuretics
-Block Na reabsorption and K excretion
-INDEPENDENT of aldosterone
MOA of ACE-I
-Inhibit ACE which blocks production of AT II
-Results in lack of bradykinin breakdown (vasodilator)
-Dilate efferent arteriole of kidney
MOA of calcium channel blockers
Inhibits Ca influx (contraction) of cardiac/vascular smooth muscle
Types of Ca channel blockers
MOA of dihydropyridines
Inhibits Ca influx into VASCULAR smooth muscle
MOA of non-dihydropyridines
Inhibits Ca influx into CARDIAC smooth muscle
Dihydropyridine drug examples:
Non-dihydropyridine drug examples:
First line options for HTN:
1. Thiazide diuretics
4. Ca Channel blockers
Which drugs are first line for HTN in DM and CKD patients?
ARBs and ACE-I
How do thiazides affect electrolytes?
DECREASE K, Na
INCREASE Ca, gluc, uric acid
How do loop diuretics affect electrolytes?
DECREASE everything (K, Na, Ca, Mg) EXCEPT uric acid
Which drugs should be given cautiously with sulfa allergic pts?
What is a rare but serious ADE of ACE-I and ARBs?
What is spironolactone commonly used for?
Class IV heart failure
(Aldosterone blocker diuretic)
How are K+ sparing diuretics used for HTN?
In combo w/thiazides
Which drug can be used for migraine prophylaxis?
-Verapamil (non-dihydro CCB)
-Can cross BBB
Drug examples of aldosterone blocker diuretics:
Drug examples of K+ sparing diuretics:
What are examples of ARBs?
Which drugs have interactions with K+ supplements, sparing diuretics, and NSAIDs?
Why shouldn't nifedipine be used sublingually?
Reported increase risk for MI and death