Hydralazine (Apresoline)

Question 1

Hydralazine (Apresoline) class

Answer 1

Direct acting arterial vasodilator

Question 2

Hydralazine (Apresoline) MOA

Answer 2

Hyperpolarizes both smooth muscle cells and activates guanylate cyclase to produce vasorelaxation

Question 3

Hydralazine (Apresoline) dosage

Answer 3

5-20 mg IV bolus

Question 4

Hydralazine (Apresoline) characteristics

Answer 4

O: 5-20 min

P:15-30 min

D: 2-4 hrs

Question 5

Hydralazine (Apresoline) E/M

Answer 5

M: hepatic

E: renal

H/L: 2-8 hrs (clinical effect 1-8 hrs)

Question 6

Hydralazine (Apresoline) considerations

Answer 6

May reduce response to Epi
Enhanced effects on pts on diuretics, MAOIs, diazoxide

Produces reflex SNS stimulation w/ increases in HR & contractility

Afterload reducer

Question 7

Hydralazine (Apresoline) supply

Answer 7

20mg/ml