Xanax (Alprazolam)

Question 1

Xanax (Alprazolam) class

Answer 1

Benzodiazepine

Question 2

Xanax (Alprazolam) MOA

Answer 2

Enhances affinity of receptors for GABA, longer opening of Cl channels, resulting in hyperpolarization of postsynaptic membrane

Question 3

Xanax (Alprazolam) dosage

Answer 3

PO: 0.25 - 2mg 2-3 x per day

Question 4

Xanax (Alprazolam) characteristics

Answer 4

O: 1-2 hrs

P: 1-2 hrs

D: 12-15 hrs

H/L: 11.2 hrs

Question 5

Xanax (Alprazolam) E/M

Answer 5

M: CYP 450

E: renal

Question 6

Xanax (Alprazolam) considerations

Answer 6

To c/c dosage should be reduced by no more than 0.5mg every 3 days to prevent withdrawal seizures

C/I: known hypersensitivity, acute narrow angel glaucoma, pts taking ketoconazole or itraconazole. Pregnancy has increased risk of congenital abnormalities