Hyperlipidemia Flashcards Preview

NUR 325 Fundamentals of Pathopharmacology > Hyperlipidemia > Flashcards

Flashcards in Hyperlipidemia Deck (12)
Loading flashcards...
1
Q

What is the MOA of atorvastatin?

A

Inhibits HMG-CoA reductase so less cholesterol is produced by liver and liver makes more LDL receptors to pull LDL from the blood.

2
Q

What are the adverse reactions with HMG-CoA Reductase Inhibitors?

A

Myopathy
Rhabdomyolysis
Hepatotoxicity

3
Q

When should HMG-CoA reductase inhibitors be taken?

A

Most are taken at night since that is when the liver produces cholesterol.

4
Q

What is the MOA of gemfibrozil?

A

Clearance of VLDLs

Breakdown of triglycerides

5
Q

What are adverse reactions with gembrizol?

A

Dyspepsia
Gallstones
Myopathy

6
Q

What is the MOA of ezetimibe?

A

Blocks absorption of cholesterol in jejunum

7
Q

What are adverse reactions with ezetimibe?

A

Headache
Myalgia & arthralgia
Abdominal pain
Diarrhea

8
Q

MAO of atorvastatin (Lipitor)

A
Inhibiting HMG-CoA reductase
Less cholesterol is produced by liver
Liver makes more LDL receptors 
More LDL is removed from the blood
Not making as much cholesterol 
Removing more LDL from the blood
NOT A PERMANENT DROP IN LEVELS
Need to keep taking the drug 
Stabilize plaque and decrease inflammation
9
Q

MAO of simvastatin (Zocor)

A
Inhibiting HMG-CoA reductase
Less cholesterol is produced by liver
Liver makes more LDL receptors 
More LDL is removed from the blood
Not making as much cholesterol 
Removing more LDL from the blood
NOT A PERMANENT DROP IN LEVELS
Need to keep taking the drug 
Stabilize plaque and decrease inflammation
10
Q

MAO of rosuvastatin (Crestor)

A
Inhibiting HMG-CoA reductase
Less cholesterol is produced by liver
Liver makes more LDL receptors 
More LDL is removed from the blood
Not making as much cholesterol 
Removing more LDL from the blood
NOT A PERMANENT DROP IN LEVELS
Need to keep taking the drug 
Stabilize plaque and decrease inflammation
11
Q

Adverse reactions of atorvastatin, simvastatin, rosuvastatin

A
  • Myopathy
  • Rhabdomyolysis
  • Breakdown of muscle fibers
  • Acute kidney failure
  • Hepatotoxicity
12
Q

Other meds used to treat HLD

A
Bile acid sequestrants
cholestyramine (Questran) 
Niacin 
Fibric acid derivative (Fibrates)
Fish oil