What is the MOA of atorvastatin?
Inhibits HMG-CoA reductase so less cholesterol is produced by liver and liver makes more LDL receptors to pull LDL from the blood.
What are the adverse reactions with HMG-CoA Reductase Inhibitors?
Myopathy
Rhabdomyolysis
Hepatotoxicity
When should HMG-CoA reductase inhibitors be taken?
Most are taken at night since that is when the liver produces cholesterol.
What is the MOA of gemfibrozil?
Clearance of VLDLs
Breakdown of triglycerides
What are adverse reactions with gembrizol?
Dyspepsia
Gallstones
Myopathy
What is the MOA of ezetimibe?
Blocks absorption of cholesterol in jejunum
What are adverse reactions with ezetimibe?
Headache
Myalgia & arthralgia
Abdominal pain
Diarrhea
MAO of atorvastatin (Lipitor)
Inhibiting HMG-CoA reductase Less cholesterol is produced by liver Liver makes more LDL receptors More LDL is removed from the blood Not making as much cholesterol Removing more LDL from the blood NOT A PERMANENT DROP IN LEVELS Need to keep taking the drug Stabilize plaque and decrease inflammation
MAO of simvastatin (Zocor)
Inhibiting HMG-CoA reductase Less cholesterol is produced by liver Liver makes more LDL receptors More LDL is removed from the blood Not making as much cholesterol Removing more LDL from the blood NOT A PERMANENT DROP IN LEVELS Need to keep taking the drug Stabilize plaque and decrease inflammation
MAO of rosuvastatin (Crestor)
Inhibiting HMG-CoA reductase Less cholesterol is produced by liver Liver makes more LDL receptors More LDL is removed from the blood Not making as much cholesterol Removing more LDL from the blood NOT A PERMANENT DROP IN LEVELS Need to keep taking the drug Stabilize plaque and decrease inflammation
Adverse reactions of atorvastatin, simvastatin, rosuvastatin
- Myopathy
- Rhabdomyolysis
- Breakdown of muscle fibers
- Acute kidney failure
- Hepatotoxicity
Other meds used to treat HLD
Bile acid sequestrants cholestyramine (Questran) Niacin Fibric acid derivative (Fibrates) Fish oil
