Hyperlipidemia

Question 1

What is the normal range for cholesterol?

Answer 1

100-200

Question 2

What are the HDL goals in men and women?

Answer 2

Women >45 mg/dL
Men >55 mg/dL
Optimal >60

Question 3

What is the goal for LDL?

Answer 3

<100 mg/dL

Question 4

What is the range for triglycerides?

Answer 4

40-150

Question 5

What is the ideal ratio of LDL to HDL in men and women?

Answer 5

Men: <5.0
Women: <4.5

Question 6

What is the mechanism of action for HMG-CoA reductase inhibitors?

Answer 6

Inhibiting HMG-CoA reductase
Less cholesterol is produced by liver
Liver makes more LDL receptors
More LDL is removed from the blood
Stabilizes plaque and decreases inflammation

Question 7

What are adverse reactions of HMG-CoA reductase inhibitors?

Answer 7

Myopathy (muscle weakness)
Rhabdomyolysis
Hepatotoxicity

Question 8

What medications are HMG-CoA reductase inhibitors?

Answer 8

Atorvastatin
Simvastatin
Rosuvastatin

Question 9

What medication is a cholesterol absorption inhibitor?

Answer 9

Ezetimibe

Question 10

What is the mechanism of action of Ezetimibe?

Answer 10

Blocks absorption of cholesterol in Jejunum. Dietary, cholesterol secreted in bile. 2nd line therapy to statins.