Hyperlipidemia

Question 1

What is the criteria for metabolic syndrome

Answer 1

3/5 or more of the following: BP130/85 or higher (or on meds), HDL<50 in females and <40 in males, TG>150 or on meds, Waist > 35 in. in females and 40 in. in males, fasting blood sugar > 100

Question 2

Which medications can induce dyslipidemia

Answer 2

Elevate LDLs: thiazide diuretics, steroids/glucocorticoids
Elevate TG: estrogen, thiazide diuretics, glucocorticoids

Question 3

Non pharmacological management of dyslipidemia

Answer 3

smoking cessation, weight loss, exercise, cholesterol control, nutrition changes BP management, Blood sugar management,

Question 4

pharmacologic treatment of dyslipedemia/ triglyceridemia

Answer 4

Atherogenic control (LDL): statins, cholesterol absorption inhibitors bile acid sequestrants, PCSK9 inhibitors, Bempedoic Acid (ACL inhibitor
Triglyceride control: statins, omega3 polyunsaturated fats, Niacin, Fibric acid derivatives

Question 5

Statin keypoints

Answer 5

Rosuvastatin/ Pravastatin are hydraphillic and have the least drug interaction, there is increased risk of diabetes, doesn’t need dose modifications with renal impairment, Category x drug in pregnancy