Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Immunology > Hypersensitivity and Allergy > Flashcards

Hypersensitivity and Allergy Flashcards

1
Q

What is the pathologic immune mechanism of type I hypersensitivity reactions?

A

IgE antibody, Th2 cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What are the mechanisms of tissue injury in type I hypersensitivity reactions?

A

Mast cells, eosinophils, and their mediators

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What is the pathologic immune mechanism of type II hypersensitivity reactions?

A

IgM, IgG antibodies against cell surface or extracellular matrix antigens

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What are the mechanisms of tissue injury in type II hypersensitivity reactions?

A

Opsonization and phagocytosis of cells
Complement- and Fc receptor-mediated recruitment and activation of leukocytes
Abnormalities in cellular functions, such as hormone receptor signaling or neurotransmitter blockade

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What is the pathologic immune mechanism of type III hypersensitivity reactions?

A

Immune complexes of circulating antigens and IgM or IgG antibodies

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What are the mechanisms of tissue injury in type III hypersensitivity reactions?

A

Deposition in blood vessel walls and tissues
Complement- and Fc receptor-mediated recruitment and activation of leukocytes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What are the pathologic immune mechanism of type IV hypersensitivity reactions?

A
  1. CD4+ T cells (Th1 and Th17 cells)
  2. CD8+ CTLs
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What are the mechanisms of tissue injury in type IV hypersensitivity reactions?

A
  1. Cytokine-meditated inflammation and macrophage activation
  2. Direct target cell killing, cytokine-mediated inflammation
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What is the mechanism of type VIa hypersensitivity reactions?

A

Th1 cells, resulting in macrophage activation
(a = 1st letter of alphabet, Th1)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What is the mechanism of type IVb hypersensitivity reactions?

A

Th2 cells, resulting in eosinophil and mast cell activation
(b = 2nd letter of alphabet, Th2)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What are some examples of type IVa hypersensitivity reactions?

A

Maculopapular drug eruption, fixed drug eruption, poison ivy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What is an example of a type IVb hypersensitivity reaction?

A

DRESS

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What is the mechanism of type IVc hypersensitivity reactions?

A

CTLs, granzymes, perforin
(c = cytotoxic)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What is an example of a type IVc hypersensitivity reaction?

A

SJS/TEN

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What is the mechanism of type IVd hypersensitivity reactions?

A

Th17 cells, resulting in neutrophil activation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What is an example of a type IVd hypersensitivity reaction?

A

AGEP, pustular psoriasis

17
Q

Which size complexes are more likely to be deposited in blood vessels?

A

Small immune complexes

18
Q

Which size complexes are more likely to be cleared by phagocytes?

A

Large immune complexes

19
Q
A

Immunology (10 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions