Immunologic Tolerance and Autoimmunity

Question 1

What are four functions of TGF-B?

Answer 1

1) Inhibits T cell and classical macrophage activation
2) Regulates T cell differentiation, increasing Treg and Th17 and decreasing Th1 and Th2
3) Induces class-switching to IgA
4) Promotes tissue repair by promoting collagen synthesis, matrix-modifying enzyme production

Question 2

What are two functions of IL-10?

Answer 2

1) Inhibition of production of IL-12 by activated DCs, thereby suppressing IFN-y production
2) Inhibition of expression of costimulators and class II MHC molecules on DCs and macrophages

Question 3

Which virus contains a gene homologous to the IL-10 gene?

Answer 3

EBV

Question 4

Which HLA alleles are associated with type 1 diabetes?

Answer 4

DRB10301-DQA10501-DQB10201
DRB10401-DQA10301-DQB10302
DRB1*030/0401 heterozygotes

Question 5

Which HLA alleles are associated with rheumatoid arthritis?

Answer 5

DRB1

Question 6

Which HLA allele is associated with multiple sclerosis?

Answer 6

DRB1*1501

Question 7

Which HLA alleles are associated with SLE?

Answer 7

DRB10301
DRB11501

Question 8

Which HLA allele is associated with ankylosing spondylitis?

Answer 8

B27, mainly B2705 and B2702

Question 9

Which HLA allele is associated with celiac disease?

Answer 9

DQA10501-DQB10201 haplotype