Hypersensitivity Mediators (more!) Flashcards Preview

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Flashcards in Hypersensitivity Mediators (more!) Deck (12):
1

Associated with Th2 cells and lead to Ig class switching in B cells to produce IgE

IL-4 & IL-13

2

Promote survival and activation of eosinophils

IL-3, IL-5 & GM-CSF

3

What produces IL-5? What is IL-5's function?

Th2 lymphocytes
Prolongs survival of eosinophils
Enhances leukotriene production and cytotoxicity for parasites

4

Chemotactic for T cells and Eosinophils

RANTES (CCL5) and Eotaxin (CCL11)

CCR3 receptor on eosinophils for Eotaxin

5

Early phase mediator, released by mast cells and basophils ONLY, short half life, toxic to parasites, increases vascular permeability, causes smooth muscle contraction

Histamine

6

Lipid mediators, lead to eosinophil migration, smooth muscle cell contraction, vascular permeability and mucus hyper secretion

Leukotrienes: LTC4, LTD4, LTE4

7

Released solely from mast cells -- preformed stores
Two forms: alpha (constituitive) and beta (mast cells)
Remains identifiable in serum for up to 4 hours
Best marker of mast cell activation
Leads to remodeling of connective tissue matrix

Tryptase

8

Late phase response
Mast cell activation
Helminthotoxic

MBP (major basic protein)

9

Late response
Neurotoxin

EDN (eosinophil derived neurotoxin)

10

Late phase response
Same as MBP plus neurotoxic

ECP (eosinophil cationic protein)

11

Early phase mediators for Type I

Histamine
Tryptase
PGD2
Thromboxane
LTC4

12

Late phase mediators for Type I

LTB4, LTC4
PGD2, PGE2, PGF2a
Kinins
Histamine
GM-CSF, IL-5
ECP, MBP, EPO