hypersensitivity reactions

Question 1

exampls of type 1 hypersensitivity reactions

Answer 1

anaphylaxis

atopy - asthma, ezema, hayfever

Question 2

type 1 hypersensitivity mechanism

Answer 2

antigen reacts wit IgE bound to mast cells

Question 3

4 types of hypersensitivity

Answer 3

1 = anaphylactic
II = cell bound
III = immune complex
IV = delayed hypersensitivity

Question 4

type II mechanism

Answer 4

IgG or IgM binds to antigen on cell surface

(cell bound)

Question 5

examples of type II

Answer 5

autoimmune haemolytic anaemia
ITP
goodpastures
Pernicious anaemia

acute haemolytic transfusion reaction
rheumatic fever
pemphigus vulgaris/bullous pemphigoid

Question 6

type III mechanism

Answer 6

free antigen + antibody (IgG, IgA) combine

(immune complex)

Question 7

exampls of type III

Answer 7

post strep glomerulonephritis

hypersensitivity pneumonitis (esp acute phase)

SLE !!

Question 8

type IV mechanism

Answer 8

T-cell mediated

(delayed hypersensitivity)

Question 9

type OV examples

Answer 9

tuberculosis
graft vs host
allergic contact dermatitis

Multiple sclerosis
guillain barre

scabies
extrinsic allergic alveolitis

Question 10

type V mechanism (new!)

Answer 10

antibodies recognise + bind to cell surface receptors

either stimulated them or blocking ligand binding

Question 11

type V examples

Answer 11

graves

myasthenia