Hypertension & Afib

Question 1

Hypertension

Answer 1

As BP increases, so does the risk of
MI
Heart failure
Stroke
Renal disease

Question 2

BPs

Answer 2

Normal: less than 120/ less than 80
Elevated: 120-129/ less than 80
HTN stage 1: 130-139/ 80-89
HTN stage 2: 140+/ 90+
HTN crisis: 180+/ 120+

Question 3

Primary HTN

Answer 3

no identified cause

Question 4

Secondary HTN

Answer 4

Specific cause can be identified and corrected
Suspect with: Unexplained hypokalemia, Abdominal bruit over renal arteries, Variable B/P with history of tachycardia, sweating, tremor, Family Hx of renal disease

Question 5

Risk Factors for Primary Hypertension

Answer 5

Age
Alcohol
Tobacco use
Diabetes mellitus
Elevated serum lipids
Excess dietary sodium
Gender
Family history
Obesity
Ethnicity
Sedentary lifestyle
Socioeconomic status
Stress

Question 6

Pathophysiology of Primary Hypertension

Answer 6

Genetic Links
Water and sodium retention
Stress and increase sympathetic nervous system activity
Altered renin-angiotensin-aldosterone system (RAAS)
Insulin resistance and hyperinsulinemia
Endothelial dysfunction

Question 7

Clinical Manifestations HTN

Answer 7

“silent killer”
Symptoms of severe hypertension
Fatigue
Dizziness
Palpitations
Angina
Dyspnea

Question 8

Target Organ Diseases

Answer 8

Heart
-Coronary artery disease (CAD)
-Left ventricular hypertrophy (LVH)
-Congestive heart failure (CHF)
Peripheral vascular disease (PVD)
Kidneys (Nephrosclerosis)
Eyes (Retinal damage)

Question 9

Goals HTN

Answer 9

Goal:
< 140 / 90 mm Hg
< 130 / 80 mm Hg for those at high risk for / with CAD
Medications
Decrease circulating blood volume
Reduce SVR – systemic vascular resistance (“After-load”)

Question 10

Medication Therapy

Answer 10

Diuretics
Adrenergic inhibitors
Vasodilators
Angiotensin & renin inhibitors
Ca+ channel blockers

Question 11

Drug Therapy action

Answer 11

Decrease the volume of circulating blood
Reduce systemic vascular resistance

Question 12

Diuretics

Answer 12

promote sodium and water excretion, reduce plasma volume, and reduce the vascular response to catecholamines

Question 13

Adrenergic-inhibiting agents (Beta blockers)

Answer 13

act by diminishing the SNS effects that increase BP. Adrenergic inhibitors include drugs that act centrally on the vasomotor center and peripherally to inhibit norepinephrine release or to block the adrenergic receptors on blood vessels.

Question 14

Direct vasodilators

Answer 14

decrease the BP by relaxing vascular smooth muscle and reducing SVR

Question 15

Calcium channel blockers

Answer 15

increase sodium excretion and cause arteriolar vasodilation by preventing the movement of extracellular calcium into cells.

Question 16

Angiotensin-converting enzyme (ACE) inhibitors

Answer 16

inhibitors prevent the conversion of angiotensin I to angiotensin II and reduce angiotensin II (A-II)–mediated vasoconstriction and sodium and water retention.

Question 17

A-II receptor blockers (ARBs)

Answer 17

) prevent angiotensin II from binding to its receptors in the walls of the blood vessels.

Question 18

Lifestyle Modification

Answer 18

Weight reduction – weight loss of 22 lb may decrease SBP by ~ 5 – 20 mm Hg
Dietary sodium reduction - HEALTHY ADULTS <2300 mg per day
Moderation of alcohol intake
Physical activity – moderate or vigorous aerobic activity, muscle-strength training, flexibility and balance exercises
Avoidance of tobacco products

Question 19

Dietary Approaches to Stop Hypertension (DASH)

Answer 19

K+ rich foods (4700 mg/day)
Ca+ rich foods (1200 mg/day)
Decrease Na+ (2400 mg/day [1 tsp])
Limit fat calories to 27%
Fruits (6 – 8 daily)
Vegetables (4 – 5 daily)
Fat-free or low fat dairy (2 – 3 daily)
Whole grains (6 – 8 daily)
Lean meat, fish, poultry (6 oz or less daily)
Beans, seeds, nuts (4 – 5 per week)
Low fat sweets (5 or less per week)

Question 20

Psychosocial Risk Factors

Answer 20

Low socioeconomic status
Social isolation
Lack of support
Stress
Negative emotions

These activate the SNS and stress hormones

Question 21

BP Measurement in Older Adult

Answer 21

Take in both arms initially
Proper size and placement f cuff

Auscultatory Gap: Wide gap between 1st Korotkoff sound & subsequent beats
Failure to inflate cuff high enough may cause serious under-estimation of B/P
Avoid by palpating brachial / radial artery during inflation
Sensitivity to B/P changes: Reducing SBP < 120 mm Hg in those with long-standing HTN can lead to inadequate cerebral blood flow
Postprandial hypotension: Greatest drop occurs approximately 1 hour after eating
Avoid giving vaso-active medications with meals

Question 22

Hypertensive Crisis

Answer 22

SBP >180 mmHg and/or DBP >120 mmHg
Hypertensive urgency
Develops over hours to days
May not require hospitalization
Hypertensive emergency
Very severe problems can result if prompt treatment is not obtained
Rate of rise more important than absolute value

Question 23

Managing Hypertensive Crisis in the Acute Care Setting

Answer 23

Labetolol (Normodyne
Hydralazine (Apresoline

Question 24

Labetolol (Normodyne)

Answer 24

Antihypertensive, anti-anginal
Mixed alpha/beta effects
Decreases B/P without reflex tachycardia or significant reduction in HR
Reduces CO, SVR & BP
20 mg IV over 2 minutes
Usually ordered every 6 - 8 hours PRN

Question 25

Hydralazine (Apresoline)

Answer 25

Direct peripheral artery vasodilator Reduces B/P with reflex increase in HR Stroke volume Cardiac output 10 – 20 mg IV every 4 to 6 hours PRN Contraindication CAD Caution > 40 years old

Question 26

Atrial Fibrillation

Answer 26

Paroxysmal or persistent Most common dysrhythmia Prevalence increases with age Usually occurs in patients with underlying heart disease Can also occur with other disease states

Question 27

atrial flutter

Answer 27

causes a decrease in cardiac output and an increased risk of stroke

Question 28

Medications AFib

Answer 28

Long term anti-coagulation therapy: Eliquis Xarelto Pradaxa Savaysa Aspirin (on rarer occasions)

Question 29

Warfarin (Coumadin)

Answer 29

Inhibits activation of Vitamin K-dependent coagulation factors II, IX, X, Proteins C & S 48 – 72 hours to affect PT Several days for maximum effect Rationale for parenteral anticoagulant for five (5) days while therapy started Contraindicated Aspirin NSAIDS Phenytoin (Dilantin) – Use cautiously Barbiturates Vitamin, mineral, herbal supplements Wide gap of individual response to dosage Age Weight Cardiac or liver impairment Diet (Vitamin K intake?) Drug interactions Must be closely monitored & titrated Monthly PT/INR Major bleeding 1–2% Intracranial bleeding 0.1–0.5%

Question 30

Coumadin v heparin

Answer 30

Coumadin Prothrombin Time (PT) Used to monitor Warfarin Extrinsic system Slow onset, persists for 7 – 14 days 11 – 12.5 seconds INR 0.8 – 1.1 (normal range) Therapeutic range = 1.5 – 2 times control 2.0 – 3.0 Warfarin reversal agents Vitamin K: 12 – 24 hours FFP more rapid Hepato-cellular liver disease Obstructive biliary disease Heparin Partial Thromboplastin Time (PTT) Used to monitor Heparin Intrinsic system aPTT: 30 – 40 seconds PTT 60 – 70 seconds Therapeutic range = 1.5 – 2.5 times control Heparin reversal agent Protamine sulfate 1 mg : 100 units Heparin Altered very little by small doses of Heparin (5000 units SQ every 12 hours) or Enoxaparin (Lovenox) Not monitored Minimal risk of spontaneous bleeding

Question 31

Dietary Sources of Vitamin K

Answer 31

Green, leafy, vegetables Kale Collards Spinach Turnip greens Asparagus, Beet greens, Broccoli, Brussels sprouts, Cabbage, Cabbage, Celery, Cucumber, Dandelion greens, Endive, Lettuce, Mustard greens, Okra, Onions, Parsley, Peas, Rhubarb, Sauerkraut OTHERS: Bread crumbs, dry, grated, seasoned Coleslaw Noodles, spinach Prunes Pie crust, graham cracker