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Pharmacy Practice V > Hypertension Medications > Flashcards

Hypertension Medications Flashcards

1
Q

Dihydropuridine CCBs act where?

A

Peripheral vasodilation and coronary dilation

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2
Q

Nondihydropyridine CCBs act where?

A

Heart

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3
Q

What are the Dihydropyridine CCBs?

A

Amlodipine, Felodipine, and Nifedipine

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4
Q

What are the Non-Dihydropyridine CCBs?

A

Dilitazem and Verapamil

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5
Q

What are the FDA Indications of CCBs?

A

HTN, Angina (except Felodipine), AFib, and Cluster HA

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6
Q

What CCBs are approved for AFib?

A

Dilitazem and Verapamil

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7
Q

What CCBs are approved for Cluster HA?

A

Verapamil

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8
Q

What ACEs should be taken with food while the others are taken on an empty stomach?

A

Calan SR and Isoptin SR

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9
Q

What ACE can be spilt in half?

A

Isoptin SR 240

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10
Q

Are immediate release CCBs (nifedipine) preferred?

A

NO, they increase risk of hypotension and reflex tachycardia

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11
Q

Are Dilitazem and Verapamil 3A4 Inducers or Inhibitors?

A

Inhibitors

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12
Q

Since Verapamil and Dilitazem are 3A4 Inhibitors, what drugs do they increase serum concentrations of?

A
  1. Atorvastatin, Lovastatin, and Simvastatin
  2. Amiodarone, Dofetilide
  3. Uroxatral
  4. Relpax
  5. Colchicine
  6. Budesonide
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13
Q

What are the CI’s of Dihydropyridine CCBs?

A
  1. Hypersensitivity
  2. STEMI = Nifedipine CI
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14
Q

What are the AEs of Dihydropyridine CCBs?

A
  1. Peripheral Edema
  2. Flushing
  3. HA
  4. Dizzy
  5. Hypotension
  6. Gingival Hyperplasia
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15
Q

What Dihydropyridine CCB has the highest chance of peripheral edema and gingival hyperplasia?

A

Nifedipine

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16
Q

What are the CI’s of Non-Hydropyridine CCBs?

A
  1. Severe Left Ventricular Dysfunction
  2. Sick Sinus Syndrome = 1st degree AV Block
  3. SBP <90
17
Q

What can Non-Hydropyridine CCBs exacerbate?

A

Any degree of HFrEF due to negative inotropic effect

18
Q

What are the AEs of Non-Dihydropyridine CCBs?

A
  1. Edema
  2. HA
  3. Hypotension
  4. Nausea
  5. Dizzy
  6. BRADYCARDIA
  7. Constipation (V>D)
  8. Gingival Hyperplasia
19
Q

Nifedipine Adalat CC is what?

A

XR tablets, do not crush or chew

20
Q

Nifedipine Procardia XL is what?

A

Capsule

21
Q

Felodipine is what?

A

XR tablet, extensive 1st pass metabolism

22
Q

Amlodipine is what?

A

Tablet, long half life (increased with hepatic dysfunction)

23
Q

Dilitazem Cardizem is what?

A

Oral and IV

24
Q

Dilitazem Tiazac is what?

A

XR CAPSULE

25
Q

Verapamil Isoptin SR is what?

A

Extended Release

26
Q

What are the indications for Alpha-1-Blockers?

A

BPH and HTN

27
Q

What is a concern with non-compliance in Alpha-1-Blockers?

A

Risk of syncope

28
Q

What is a condition that can occur with Alpha-1 Blockers and Cataract Surgery?

A

Floppy Iris Syndrome

29
Q

What are the AEs of Alpha-1-Blockers?

A
  1. Postural Hypotension
  2. Dizzy
  3. HA
  4. Fatigue
  5. Edema
  6. Muasthenia
30
Q

When should the first dose of Alpha-1-Blockers be administered?

A

At HS, unless ER dose that can be taken in the morning with food

31
Q

What Alpha-1-Blocker capsule may be taken in the morning with food and the capsule shell may be found within stool?

A

Cardura XL

32
Q

What are the dosage forms of Cardura and Hytrin?

A

Cardura = tablets
Hytrin = capsules

33
Q

What dosage form of Catapres is TTS?

A

Transdermal Patches
7 day dosage regimen

34
Q

What is the indication for Catapres?

A

HTN

35
Q

Catapres has DDIs with what drugs?

A

BB and Tricyclic Antidepressants

36
Q

What are the AEs of Catapres?

A
  1. Hypotension
  2. CNS Depression: drowsy, fatigue, dizzy
  3. Nightmare/Vivid Dreams
  4. Bradycardia
  5. Rebound HTN/Tachycardia
  6. Dry Mouth/Constipation
37
Q

Can you abruptly DC Alpha-2-Agonist Clonidine?

A

NO

Pharmacy Practice V (19 decks)

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