Hypertension Medications

Question 1

Dihydropuridine CCBs act where?

Answer 1

Peripheral vasodilation and coronary dilation

Question 2

Nondihydropyridine CCBs act where?

Answer 2

Heart

Question 3

What are the Dihydropyridine CCBs?

Answer 3

Amlodipine, Felodipine, and Nifedipine

Question 4

What are the Non-Dihydropyridine CCBs?

Answer 4

Dilitazem and Verapamil

Question 5

What are the FDA Indications of CCBs?

Answer 5

HTN, Angina (except Felodipine), AFib, and Cluster HA

Question 6

What CCBs are approved for AFib?

Answer 6

Dilitazem and Verapamil

Question 7

What CCBs are approved for Cluster HA?

Answer 7

Verapamil

Question 8

What ACEs should be taken with food while the others are taken on an empty stomach?

Answer 8

Calan SR and Isoptin SR

Question 9

What ACE can be spilt in half?

Answer 9

Isoptin SR 240

Question 10

Are immediate release CCBs (nifedipine) preferred?

Answer 10

NO, they increase risk of hypotension and reflex tachycardia

Question 11

Are Dilitazem and Verapamil 3A4 Inducers or Inhibitors?

Answer 11

Inhibitors

Question 12

Since Verapamil and Dilitazem are 3A4 Inhibitors, what drugs do they increase serum concentrations of?

Answer 12

1. Atorvastatin, Lovastatin, and Simvastatin
2. Amiodarone, Dofetilide
3. Uroxatral
4. Relpax
5. Colchicine
6. Budesonide

Question 13

What are the CI’s of Dihydropyridine CCBs?

Answer 13

1. Hypersensitivity
2. STEMI = Nifedipine CI

Question 14

What are the AEs of Dihydropyridine CCBs?

Answer 14

1. Peripheral Edema
2. Flushing
3. HA
4. Dizzy
5. Hypotension
6. Gingival Hyperplasia

Question 15

What Dihydropyridine CCB has the highest chance of peripheral edema and gingival hyperplasia?

Answer 15

Nifedipine

Question 16

What are the CI’s of Non-Hydropyridine CCBs?

Answer 16

1. Severe Left Ventricular Dysfunction
2. Sick Sinus Syndrome = 1st degree AV Block
3. SBP <90

Question 17

What can Non-Hydropyridine CCBs exacerbate?

Answer 17

Any degree of HFrEF due to negative inotropic effect

Question 18

What are the AEs of Non-Dihydropyridine CCBs?

Answer 18

1. Edema
2. HA
3. Hypotension
4. Nausea
5. Dizzy
6. BRADYCARDIA
7. Constipation (V>D)
8. Gingival Hyperplasia

Question 19

Nifedipine Adalat CC is what?

Answer 19

XR tablets, do not crush or chew

Question 20

Nifedipine Procardia XL is what?

Answer 20

Capsule

Question 21

Felodipine is what?

Answer 21

XR tablet, extensive 1st pass metabolism

Question 22

Amlodipine is what?

Answer 22

Tablet, long half life (increased with hepatic dysfunction)

Question 23

Dilitazem Cardizem is what?

Answer 23

Oral and IV

Question 24

Dilitazem Tiazac is what?

Answer 24

XR CAPSULE

Question 25

Verapamil Isoptin SR is what?

Answer 25

Extended Release

Question 26

What are the indications for Alpha-1-Blockers?

Answer 26

BPH and HTN

Question 27

What is a concern with non-compliance in Alpha-1-Blockers?

Answer 27

Risk of syncope

Question 28

What is a condition that can occur with Alpha-1 Blockers and Cataract Surgery?

Answer 28

Floppy Iris Syndrome

Question 29

What are the AEs of Alpha-1-Blockers?

Answer 29

1. Postural Hypotension 2. Dizzy 3. HA 4. Fatigue 5. Edema 6. Muasthenia

Question 30

When should the first dose of Alpha-1-Blockers be administered?

Answer 30

At HS, unless ER dose that can be taken in the morning with food

Question 31

What Alpha-1-Blocker capsule may be taken in the morning with food and the capsule shell may be found within stool?

Answer 31

Cardura XL

Question 32

What are the dosage forms of Cardura and Hytrin?

Answer 32

Cardura = tablets Hytrin = capsules

Question 33

What dosage form of Catapres is TTS?

Answer 33

Transdermal Patches 7 day dosage regimen

Question 34

What is the indication for Catapres?

Answer 34

HTN

Question 35

Catapres has DDIs with what drugs?

Answer 35

BB and Tricyclic Antidepressants

Question 36

What are the AEs of Catapres?

Answer 36

1. Hypotension 2. CNS Depression: drowsy, fatigue, dizzy 3. Nightmare/Vivid Dreams 4. Bradycardia 5. Rebound HTN/Tachycardia 6. Dry Mouth/Constipation

Question 37

Can you abruptly DC Alpha-2-Agonist Clonidine?

Answer 37

NO